A182
trans-(1S,3R)-ACPD
>97%, solid
别名:
trans-(1S,3R)-1-Amino-1,3-cyclopentanedicarboxylic acid
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关于此项目
经验公式（希尔记法）:
C7H11NO4
化学文摘社编号:
分子量:
173.17
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
>97%
form
solid
color
white
solubility
ethanol: 0.24 mg/mL, H2O: 20 mg/mL
SMILES string
N[C@]1(CC[C@H](C1)C(O)=O)C(O)=O
Gene Information
human ... GRM1(2911), GRM2(2912), GRM3(2913), GRM4(2914), GRM6(2916), GRM7(2917), GRM8(2918)
rat ... Gria1(50592), Grik1(29559), Grin2b(24410), Grm1(24414), Grm2(24415), Grm4(24417), Grm5(24418)
Biochem/physiol Actions
Selective metabotropic glutamate receptor agonist; active enantiomer of trans-(±)-ACPD.
Other Notes
Note: under IUPAC nomenclature, this compound is designated cis.
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
D D Schoepp et al.
Neuroscience letters, 145(1), 100-104 (1992-09-28)
Metabotropic glutamate receptors are selectively activated by 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD). [3H]Glutamate binding sites in rat brain membranes were characterized in the presence of (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate, and N-methyl-D-aspartate (NMDA) to block binding to ionotropic glutamate receptors. 1S,3R-ACPD displaced a
J W McDonald et al.
European journal of pharmacology, 215(2-3), 353-354 (1992-05-14)
The role of metabotropic type excitatory amino acid receptors in brain injury was assessed using the selective metabotropic receptor agonist, (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD). Intrastriatal stereotaxic injection of 1S,3R-ACPD (250 nmol) in PND 7 rats produced little brain injury as assessed
Matthew E Larkum et al.
Journal of neurophysiology, 99(2), 683-694 (2007-11-30)
The six-layered mammalian neocortex evolved from the three-layered paleocortex, which is retained in present-day reptiles such as the turtle. Thus the turtle offers an opportunity to examine which cellular and circuit properties are fundamental to cortical function. We characterized the
G N Andrianov et al.
Hearing research, 204(1-2), 200-209 (2005-06-01)
Using immunocytochemistry and multiunit recording of afferent activity of the whole vestibular nerve, we investigated the role of metabotropic glutamate receptors (mGluR) in the afferent neurotransmission in the frog semicircular canals (SCC). Group I (mGluR1alpha) and group II (mGluR2/3) mGluR
Víctor M Blanco et al.
American journal of physiology. Heart and circulatory physiology, 294(6), H2855-H2863 (2008-05-06)
A growing number of studies support an important contribution of astrocytes to neurovascular coupling, i.e., the phenomenon by which variations in neuronal activity trigger localized changes in blood flow that serve to match the metabolic demands of neurons. However, since
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