A182
trans-(1S,3R)-ACPD
>97%, solid
别名:
trans-(1S,3R)-1-Amino-1,3-cyclopentanedicarboxylic acid
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关于此项目
经验公式（希尔记法）:
C7H11NO4
化学文摘社编号:
分子量:
173.17
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
>97%
form
solid
color
white
solubility
ethanol: 0.24 mg/mL, H2O: 20 mg/mL
SMILES string
N[C@]1(CC[C@H](C1)C(O)=O)C(O)=O
Gene Information
human ... GRM1(2911), GRM2(2912), GRM3(2913), GRM4(2914), GRM6(2916), GRM7(2917), GRM8(2918)
rat ... Gria1(50592), Grik1(29559), Grin2b(24410), Grm1(24414), Grm2(24415), Grm4(24417), Grm5(24418)
Biochem/physiol Actions
Selective metabotropic glutamate receptor agonist; active enantiomer of trans-(±)-ACPD.
Other Notes
Note: under IUPAC nomenclature, this compound is designated cis.
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
D D Schoepp et al.
Neuroscience letters, 145(1), 100-104 (1992-09-28)
Metabotropic glutamate receptors are selectively activated by 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD). [3H]Glutamate binding sites in rat brain membranes were characterized in the presence of (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate, and N-methyl-D-aspartate (NMDA) to block binding to ionotropic glutamate receptors. 1S,3R-ACPD displaced a
J W McDonald et al.
European journal of pharmacology, 215(2-3), 353-354 (1992-05-14)
The role of metabotropic type excitatory amino acid receptors in brain injury was assessed using the selective metabotropic receptor agonist, (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD). Intrastriatal stereotaxic injection of 1S,3R-ACPD (250 nmol) in PND 7 rats produced little brain injury as assessed
Matthew E Larkum et al.
Journal of neurophysiology, 99(2), 683-694 (2007-11-30)
The six-layered mammalian neocortex evolved from the three-layered paleocortex, which is retained in present-day reptiles such as the turtle. Thus the turtle offers an opportunity to examine which cellular and circuit properties are fundamental to cortical function. We characterized the