A1824
N-乙酰-5-羟色胺
≥99% (HPLC), powder, antioxidant
别名:
N-乙酰羟色胺, N-乙酰羟色胺
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C12H14N2O2
化学文摘社编号:
分子量:
218.25
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
214-916-5
MDL number:
产品名称
N-乙酰-5-羟色胺, ≥99% (HPLC), powder
InChI key
MVAWJSIDNICKHF-UHFFFAOYSA-N
InChI
1S/C12H14N2O2/c1-8(15)13-5-4-9-7-14-12-3-2-10(16)6-11(9)12/h2-3,6-7,14,16H,4-5H2,1H3,(H,13,15)
SMILES string
CC(=O)NCCc1c[nH]c2ccc(O)cc12
assay
≥99% (HPLC)
form
powder
color
white to faint yellow
mp
120-122 °C (lit.)
solubility
ethanol: 50 mg/mL
storage temp.
2-8°C
Quality Level
Gene Information
human ... MTNR1A(4543), MTNR1B(4544)
正在寻找类似产品? 访问 产品对比指南
Application
N-乙酰基-5-羟色胺已被用于治疗神经元细胞，并分析其对Krüppel样因子15（KLF15）表达的影响。
Biochem/physiol Actions
N-乙酰血清素（NAS，又称normelatonin）可以保护神经元，因为它能够防止氧化胁迫。 它还可以抑制转录因子NF-κB的作用。NAS具有抗氧化和抗衰老作用。它可以防止β-淀粉质引起的神经毒性。它有助于维持生物膜的最佳流动性能。
褪黑激素的直接前体。它由血清素和乙酰辅酶 A 在血清素 N-乙酰转移酶（褪黑激素生物合成中的限速酶）催化下形成的。该吲哚胺是褪黑激素受体的弱激动剂，对 G 蛋白刺激和 cAMP 积累的抑制有一定的作用。
General description
N-乙酰血清素 (NAS)（又称normelatonin）是色氨酸代谢途径中褪黑激素的前体。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
N-Acetylserotonin and 6-hydroxymelatonin against oxidative stress: Implications for the overall protection exerted by melatonin
A?lvarez DR, et al.
The Journal of Physical Chemistry B, 119(27), 8535-8543 (2015)
N-acetyl-serotonin (normelatonin) and melatonin protect neurons against oxidative challenges and suppress the activity of the transcription factor NF-kappaB
Lezoualch F, et al.
Journal of Pineal Research, 24(3), 168-178 (1998)
J Vanecek et al.
Endocrinology, 126(3), 1509-1513 (1990-03-01)
Melatonin's transduction mechanisms were investigated using in vitro cultured anterior hemipituitaries. Melatonin inhibited cAMP and 3',5'-cyclic GMP accumulation in neonatal rat anterior pituitary stimulated with LHRH. Maximal inhibitory effect was reached within 25 min and persisted for at least 20
Izabela Sadowska-Woda et al.
Toxicology in vitro : an international journal published in association with BIBRA, 24(3), 879-884 (2009-12-08)
beta-Cyfluthrin is one of the most widely used type II pyrethroid in agriculture. The aim of this study was to examine (1) the possibility of beta-cyfluthrin to induce oxidative stress in human erythrocytes in vitro and its effect on catalase
J K Yao et al.
Molecular psychiatry, 15(9), 938-953 (2009-04-30)
Schizophrenia is characterized by complex and dynamically interacting perturbations in multiple neurochemical systems. In the past, evidence for these alterations has been collected piecemeal, limiting our understanding of the interactions among relevant biological systems. Earlier, both hyper- and hyposerotonemia were
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持