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A2056

乙酰辅酶A 三钠盐

Name: 乙酰辅酶A 三钠盐
Brand: SIGMA

≥93% (HPLC), powder

别名:

乙酰-S-CoA, 乙酰CoA

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关于此项目

经验公式（希尔记法）:

C₂₃H₃₅N₇O₁₇P₃S · 3Na

化学文摘社编号:

102029-73-2

分子量:

875.52

NACRES:

NA.51

PubChem Substance ID:

24890621

UNSPSC Code:

41106305

MDL number:

MFCD00078858

Form:

powder

Assay:

≥93% (HPLC)

Solubility:

H₂O: 100 mg/mL

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Quality Level

300

assay

≥93% (HPLC)

form

powder

solubility

H₂O: 100 mg/mL

storage temp.

−20°C

SMILES string

O[C@H]1[C@](O[C@@H]([C@H]1OP(O)(O)=O)COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(C)=O)=O)=O)(O)=O)(O)=O)([H])N2C3=NC=NC(N)=C3N=C2.[3Na]

InChI

1S/C23H38N7O17P3S.Na/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30;/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38);/q;+1/p-1/t13-,16-,17-,18?,22-;/m1./s1

InChI key

HNLIOWFIXSPFEC-WLYMNMRISA-M

Gene Information

human ... CHAT(1103), HAT1(8520), KAT2A(2648), KAT2B(8850), KAT5(10524)
mouse ... HAT1(107435), KAT2A(14534), KAT2B(18519), KAT5(81601)
rat ... HAT1(296501), KAT2A(303539), KAT2B(301164), KAT5(192218)

Application

乙酰辅酶A是酶促的乙酰转移反应中酰基的必需辅助因子和载体。可通过线粒体中丙酮酸的氧化脱羧、长链脂肪酸的氧化或某些特定氨基酸的氧化降解，可形成乙酰辅酶A。乙酰辅酶A是柠檬酸循环（克雷布氏循环）的起始化合物。同时，它也是脂质生物合成的关键前体、所有脂肪酸碳的来源。乙酰辅酶A可正向调节丙酮酸羧化酶的活性。乙酰辅酶A是神经递质乙酰胆碱的前体。组蛋白乙酰化酶（HAT）使用乙酰辅酶A作为乙酰基的供体，用于组蛋白和非组蛋白蛋白的翻译后乙酰化反应。

酶促的乙酰转移反应中的必需辅助因子。

Biochem/physiol Actions

乙酰辅酶A是酶促的乙酰转移反应中酰基的必需辅助因子和载体。

乙酰辅酶A是酶促的乙酰转移反应中酰基的必需辅助因子和载体。它可通过线粒体中丙酮酸的氧化脱羧、长链脂肪酸的氧化或某些特定氨基酸的氧化降解而形成。乙酰辅酶A是柠檬酸循环（克雷布氏循环）的起始化合物。它也是脂质生物合成的关键前体，所有脂肪酸碳的来源。乙酰辅酶A可正向调节丙酮酸羧化酶的活性。它是神经递质乙酰胆碱的前体。组蛋白乙酰化酶（HAT）使用乙酰辅酶A作为乙酰基的供体，用于组蛋白和非组蛋白蛋白的翻译后乙酰化反应。

Preparation Note

酶法制备

Other Notes

如需更多技术信息以及辅酶A衍生物的完整列表，请访问乙酰转移试剂资源。

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

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PloS one, 11(3), e0150454-e0150454 (2016-03-02)

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全球贸易项目编号

货号	GTIN
A2056-100MG	04061835551170
A2056-5MG	04061835551200
A2056-1MG	04061833343999
A2056-10MG	04061835551187
A2056-25MG	04061835551194

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