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Merck
CN

A2169

3′-叠氮-3′-脱氧胸苷

≥98% (HPLC), powder, reverse transcriptase inhibitor

别名:

AZT, ZDV, 叠氮胸苷, 齐多夫定

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关于此项目

经验公式（希尔记法）:
C10H13N5O4
化学文摘社编号:
30516-87-1
分子量:
267.24
NACRES:
NA.77
PubChem Substance ID:
24278143
UNSPSC Code:
12352200
MDL number:
MFCD00006536
Beilstein/REAXYS Number:
3595791

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产品名称

3′-叠氮-3′-脱氧胸苷, ≥98% (HPLC)

InChI

1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1

SMILES string

CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O

InChI key

HBOMLICNUCNMMY-XLPZGREQSA-N

assay

≥98% (HPLC)

form

powder

mp

113-115 °C (lit.)

solubility

H2O: 50 mg/mL

storage temp.

−20°C

Quality Level

200

Gene Information

human ... HIVE1(3095)
mouse ... Slc29a1(63959)

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相关类别

Application

3′-叠氮-3′-脱氧胸苷已作为逆转录酶抑制剂抑制病毒基因组整合和作为抗菌剂评估其抗沙门氏菌活性。

Biochem/physiol Actions

叠氮胸苷 (AZT) 是一种胸苷类似物，是 HIV-1 病毒的逆转录酶抑制剂。叠氮胸苷已被证明会降低 CRISPR 介导的同源定向修复 (HDR) 的效率。
对 HIV-1 病毒有效的逆转录酶抑制剂。

Features and Benefits

这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H341,H351

Hazard Classifications

Carc. 2 - Muta. 2

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCW0371
MKCW5948
MKCS1355
MKCR8766
MKCQ4508

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Small Molecule CRISPR Enhancers

Modulation of homology-directed repair (HDR) within the context of CRISPR-genome editing has led to the identification of small molecules that enhance CRISPR-mediated HDR efficiency in various cell types.

CRISPR小分子增强剂

业内研究了CRISPR基因组编辑背景下的HDR调控，发现各种细胞类型中增强CRISPR介导的HDR效率的小分子。

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