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Merck
CN

A2202

ω-Agatoxin TK

~98% (HPLC), powder

别名:

ω-Aga-TK

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关于此项目

经验公式(希尔记法):
C215H337N65O70S10
化学文摘社编号:
分子量:
5273.02
UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
Form:
powder
Assay:
~98% (HPLC)
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assay

~98% (HPLC)

Quality Level

form

powder

solubility

H2O: soluble (Aqueous stock solution is stable for 1 month at 2-8 °C and for several months at -20 °C.)

storage temp.

−20°C

Gene Information

human ... CACNA1A(773)
mouse ... CACNA1A(12286)
rat ... CACNA1A(25398)

Biochem/physiol Actions

Toxin found in the venom of the funnel web spider, Agelenopsis aptera. Potent, selective P-type and Q-type calcium-channel blocker, without effect on L-type, N-type, or T-type calcium channels. Used to differentiate the types of calcium channel active during various physiological processes


存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Q Q Sun et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 17(18), 6839-6849 (1997-09-15)
The primary sensory Rohon-Beard (R-B) neurons of Xenopus larvae are highly analogous to the C fibers of the mammalian pain pathway. We explored the actions of 5-HT by studying the modulation of Ca2+ currents. In approximately 80% of the acutely
Y Q Lin et al.
Journal of the autonomic nervous system, 73(1), 26-37 (1998-11-10)
The sympathetic preganglionic nerve terminals of the rat superior cervical ganglion were loaded with the calcium indicator oregon green 488 BAPTA-1 to measure the change in calcium concentration in the terminal boutons, (delta[Ca2+]b) following short (1 or 5 impulses) and
T Teramoto et al.
Biochemical and biophysical research communications, 196(1), 134-140 (1993-10-15)
In the course of purification of omega-Aga-IVA, a specific P-type calcium channel blocker, from the venom of Agelenopsis aperta we discovered a novel peptide. This peptide, named omega-agatoxin Tsukuba (omega-Aga-TK), also blocked P-type channels and was twelve times more abundant



全球贸易项目编号

货号GTIN
A2202-.1MG04061833627006