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A2263

α-天麻素

From Amanita phalloides, ≥85% (HPLC), RNA polymerase II and III inhibitor, powder

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关于此项目

经验公式（希尔记法）:
C39H54N10O14S
化学文摘社编号:
23109-05-9
分子量:
918.97
NACRES:
NA.32
PubChem Substance ID:
24890639
UNSPSC Code:
12352202
EC Number:
245-432-2
MDL number:
MFCD00215842
Beilstein/REAXYS Number:
1071138
Assay:
≥85% (HPLC)
Form:
powder
Quality level:
200
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产品名称

α-天麻素, from Amanita phalloides, ≥85% (HPLC), powder

biological source

Amanita phalloides

Quality Level

200

assay

≥85% (HPLC)

form

powder

mol wt

918.97  g/mol

color

white to light yellow

mp

254-255 °C (lit.)

solubility

H2O: 1.0 mg/mL

ε (extinction coefficient)

13,500 at 310 nm in H2O at 1 M

storage temp.

−20°C

SMILES string

CCC(C)C1NC(=O)CNC(=O)C2Cc3c([nH]c4cc(O)ccc34)S(=O)CC(NC(=O)CNC1=O)C(=O)NC(CC(N)=O)C(=O)N5CC(O)CC5C(=O)NC(C(C)C(O)CO)C(=O)N2

InChI

1S/C39H54N10O14S/c1-4-16(2)31-36(60)42-11-29(55)43-25-15-64(63)38-21(20-6-5-18(51)7-22(20)46-38)9-23(33(57)41-12-30(56)47-31)44-37(61)32(17(3)27(53)14-50)48-35(59)26-8-19(52)13-49(26)39(62)24(10-28(40)54)45-34(25)58/h5-7,16-17,19,23-27,31-32,46,50-53H,4,8-15H2,1-3H3,(H2,40,54)(H,41,57)(H,42,60)(H,43,55)(H,44,61)(H,45,58)(H,47,56)(H,48,59)

InChI key

CIORWBWIBBPXCG-UHFFFAOYSA-N

相关类别

Application

α-鹅膏毒素已用于：
  • 在免疫荧光测定之前诱导NT2细胞中的转录停滞
  • 诱导小鼠肾组织中的肾毒性
  • 通过细胞活力测定、彗星测定和染色体畸变测定诱导和分析小鼠骨髓细胞的遗传毒性

Biochem/physiol Actions

抑制真核细胞RNA聚合酶II和III；不抑制RNA聚合酶I或细菌RNA聚合酶；抑制哺乳动物蛋白合成。
蘑菇的主要有毒成分鬼笔鹅膏可抑制真核细胞RNA聚合酶II和III，但不抑制RNA聚合酶I或细菌RNA聚合酶。抑制哺乳动物蛋白合成。

Preparation Note

以1 mg/ml的分装储备液冻存在-20°C。 反复冻融也不会降解。 仅在使用前再用适当的缓冲液进行稀释。产品会被浓酸或碱所破坏。

Disclaimer

当避光冷冻保存两年后，通过HPLC可发现保留的样品大于99％。

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

hcodes

H300,H373

Hazard Classifications

Acute Tox. 1 Oral - STOT RE 2

target_organs

Kidney,Blood,Liver,Gastrointestinal tract,Respiratory Tract,Central nervous system

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

涉药品监管产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000424280
0000424280
0000377163
0000377163
SLCQ3066

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全球贸易项目编号

货号GTIN
A2263-100MG04061833228029
A2263-1MG04061833349946

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