Anti-ADAM-8, Propeptide Domain antibody produced in rabbit

ADAM8, a transmembrane glycoprotein, also known as MS2 and CD156, is a member of the metalloproteinase family containing disintegrin-like domains (ADAMs). ADAM8 is up-regulated in the central nervous system following neurogeneration and activation of glia, astrocytes, and microglia, suggesting that it may have a role in neuron-glia interactions. ADAM8 stimulates osteoclasts, suggesting a role in cell adhesion and cell fusion.
Anti-ADAM-8, propeptide domain antibody localizes human, porcine, and rat ADAM8 and does not react with other ADAMs. In immunoblotting assays against the reduced protein, the antibody recognizes 52kDa and 70kDa bands in conditioned media or cell lysates. In culture media, the 52kDa form is predominant.

synthetic peptide corresponding to the propeptide domain of human ADAM-8.

Anti-ADAM-8, propeptide domain antibody can be used for western blotting assays at a dilution of 1:1,000.

Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.

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