生物来源
synthetic
质量水平
方案
≥99%
表单
powder
溶解性
water: 50 mg/mL, clear, faintly to light yellow
SMILES字符串
O[N+]([O-])=O.Nc1ncc2[nH]cnc2n1
InChI
1S/C5H5N5.HNO3/c6-5-7-1-3-4(10-5)9-2-8-3;2-1(3)4/h1-2H,(H3,6,7,8,9,10);(H,2,3,4)
InChI key
PGDNOZBGABWZLD-UHFFFAOYSA-N
应用
2-Aminopurine (2-AP) is used to specifically inhibit double-stranded RNA-dependent protein kinase, protein kinase R (PKR).
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Renata M S Pereira et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(2), 617-626 (2009-10-09)
The evolution of Leishmania infection depends on the balance between microbicidal and suppressor macrophage functions. Double-stranded RNA (dsRNA)-activated protein kinase R (PKR), a classic antiviral protein, is able to regulate a number of signaling pathways and macrophage functions. We investigated
Junpei Teramachi et al.
Experimental cell research, 316(19), 3254-3262 (2010-08-24)
Double-stranded RNA-dependent protein kinase (PKR) plays a critical role in antiviral defence of the host cells. PKR is also involved in cell cycle progression, cell proliferation, cell differentiation, tumorigenesis, and apoptosis. We previously reported that PKR is required for differentiation
Michael E Lindquist et al.
Virology, 413(1), 103-110 (2011-03-08)
We performed experiments to determine the effect of PKR activation on respiratory syncytial virus (RSV) replication. We first determined that RSV infection activates PKR which induces the phosphorylation of eIF2α, resulting in the formation of host stress granules. We used
Yasumi Endoh et al.
Journal of immunology (Baltimore, Md. : 1950), 182(4), 2258-2268 (2009-02-10)
The S100 calcium-binding proteins S100A8 and S100A9 are elevated systemically in patients with viral infections. The S100A8-S100A9 complex facilitated viral replication in human CD4(+) T lymphocytes latently infected with HIV-1- and S100A8-induced HIV-1 transcriptional activity. Mechanisms inducing the S100 genes
Wen-Jun Liu et al.
Virus research, 204, 47-57 (2015-04-23)
Classical swine fever (CSF) is a highly contagious swine disease that is responsible for economic losses worldwide. Protein kinase R (PK)R is an important protein in the host viral response; however, the role of PKR in CSFV infection remains unknown.
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