跳转至内容
Merck
CN

A2408

S-(5′-腺苷)-L-甲硫氨酸 甲苯磺酸盐

≥80% (HPLC), ≥80% (spectrophotometric assay)

别名:

AdoMet, SAM 甲苯磺酸盐

登录 查看组织和合同定价。

选择尺寸


关于此项目

经验公式(希尔记法):
C15H23N6O5S · C7H7O3S · xC7H8O3S
化学文摘社编号:
分子量:
570.64 (free base basis)
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
Form:
powder
Assay:
≥80% (HPLC)
≥80% (spectrophotometric assay)
Solubility:
H2O: 100 mg/mL
Biological source:
synthetic (Organic)
Color:
white to off-white
技术服务
需要帮助?我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助?我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

S-(5′-腺苷)-L-甲硫氨酸 甲苯磺酸盐, ≥80% (HPLC), ≥80% (spectrophotometric assay)

SMILES string

O=C(O[H])[C@](N([H])[H])([H])C([H])([H])C([H])([H])[S@+](C([H])([H])[H])C([H])([H])[C@@]([C@](O[H])([H])[C@@]1([H])O[H])([H])O[C@]1([H])N2C3=C(N=C2[H])C(N([H])[H])=NC([H])=N3.O=S(C4=C([H])C([H])=C(C([H])([H])[H])C([H])=C4[H])([O-])=O

InChI

1S/C15H22N6O5S.C7H8O3S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;1-6-2-4-7(5-3-6)11(8,9)10/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25);2-5H,1H3,(H,8,9,10)/t7-,8+,10+,11+,14+,27?;/m0./s1

InChI key

VHPOFDUCFKOUHV-XKGORWRGSA-N

biological source

synthetic (Organic)

assay

≥80% (HPLC)
≥80% (spectrophotometric assay)

form

powder

composition

p-Toluenesulfonate content, 1.6-4.4 mol/mol

color

white to off-white

solubility

H2O: 100 mg/mL

shipped in

dry ice

storage temp.

−20°C

Quality Level

Application

S-(5′-腺苷)-L-甲硫氨酸-对甲苯磺酸盐已用于细胞增殖检测。它也用于甲基化检测。

Biochem/physiol Actions

S-(5′-腺苷)-L-甲硫氨酸(SAM)在正常肝细胞和正常结肠上皮细胞中抗凋亡,但在人肝细胞癌(HCC)HepG2细胞和结肠癌细胞中促凋亡。
甲基供体;酶催化甲基化的辅因子,包括儿茶酚O-甲基转移酶(COMT)和DNA甲基转移酶(DNMT)。
甲基供体;酶催化甲基化的辅因子,包括儿茶酚O-甲基转移酶(COMT)和DNA甲基转移酶(DNMT)。 虽然所有细胞中都存在,但在85%甲基化反应发生的肝脏中富集。 它还参与调控肝功能、生长和损伤反应。

Disclaimer

该材料在室温下不稳定。

General description

S-(5′-腺苷)-L-甲硫氨酸-对甲苯磺酸盐用于治疗抑郁症、肝硬化、胆汁淤积症和退行性关节病变。

flash_point_c

Not applicable

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本?

如果您需要特殊版本,可通过批号或批次号查找具体证书。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Allison B Norvil et al.
Nucleic acids research, 48(7), 3761-3775 (2020-03-04)
We have previously shown that the highly prevalent acute myeloid leukemia (AML) mutation, Arg882His, in DNMT3A disrupts its cooperative mechanism and leads to reduced enzymatic activity, thus explaining the genomic hypomethylation in AML cells. However, the underlying cause of the
Le Thanh Mai Pham et al.
Enzyme and microbial technology, 82, 66-73 (2015-12-18)
Using bioinformatic homology search tools, this study utilized sequence phylogeny, gene organization and conserved motifs to identify members of the family of O-methyltransferases from lignin-degrading fungus Phanerochaete chrysosporium. The heterologous expression and characterization of O-methyltransferases from P. chrysosporium were studied.
Lupus autoimmunity altered by cellular methylation metabolism
Yang ML, et al.
Autoimmunity, 46(1), 21-31 (2013)
Dietary supplement S-adenosyl-L-methionine (AdoMet) effects on plasma homocysteine levels in healthy human subjects: a double-blind, placebo-controlled, randomized clinical trial
Thompson MA, et al.
Journal of Alternative and Complementary Medicine (New York, N.Y.), 15(5), 523-529 (2009)
Negative regulation of interferon-induced transmembrane protein 3 by SET7-mediated lysine monomethylation
Shan Z, et al.
The Journal of biological chemistry, 288(49), 35093-35103 (2013)

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持