A2487
磺胺甲恶唑，成品溶液
Ready Made Solution, 100 mg/mL in DMSO
别名:
复方新诺明, TMP-SMX
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关于此项目
经验公式（希尔记法）:
C14H18N4O3 · 5 C10H11N3O3S
化学文摘社编号:
分子量:
1556.71
MDL编号:
UNSPSC代码:
51102829
NACRES:
NA.85
质量水平
表单
liquid
ready-to-use solution
浓度
100 mg/mL in DMSO
颜色
colorless to faint yellow
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
fungi
parasites
作用机制
DNA synthesis | interferes
运输
dry ice
储存温度
−20°C
SMILES字符串
[S](=O)(=O)(Nc4n[o]c(c4)C)c3ccc(cc3)N.Nc1nc(c(cn1)Cc2cc(c(c(c2)OC)OC)OC)N
InChI
1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)
InChI key
WZRJTRPJURQBRM-UHFFFAOYSA-N
相关类别
应用
复方新诺明已被用作抗菌剂。
生化/生理作用
复方新诺明是甲氧苄啶和磺胺甲恶唑的组合，可通过阻止核苷酸的生物合成来干扰叶酸在细菌细胞中的细胞代谢。甲氧苄啶与二氢叶酸还原酶（DHFR）结合，从而抑制二氢叶酸（DHF）还原为四氢叶酸（THF），从而产生抗菌作用。新诺明通过阻止对氨基苯甲酸向辅酶二氢叶酸的转化来干扰敏感微生物中核酸的合成。这些作用的最终结果是抑制胸腺嘧啶核苷的合成，从而阻止细菌 DNA 的合成。
包装
1ml
制备说明
使用甲氧苄啶：磺胺甲恶唑的 1：5 混合物制备
其他说明
保存于密闭容器内，置于干燥通风处。
警示用语：
Warning
危险声明
危险分类
Aquatic Chronic 3 - Repr. 2
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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