表单
liquid
ready-to-use solution
质量水平
浓度
100 mg/mL in DMSO
颜色
colorless to faint yellow
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
fungi
parasites
作用机制
DNA synthesis | interferes
运输
dry ice
储存温度
−20°C
SMILES字符串
[S](=O)(=O)(Nc4n[o]c(c4)C)c3ccc(cc3)N.Nc1nc(c(cn1)Cc2cc(c(c(c2)OC)OC)OC)N
InChI
1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)
InChI key
WZRJTRPJURQBRM-UHFFFAOYSA-N
相关类别
应用
复方新诺明已被用作抗菌剂。
生化/生理作用
复方新诺明是甲氧苄啶和磺胺甲恶唑的组合，可通过阻止核苷酸的生物合成来干扰叶酸在细菌细胞中的细胞代谢。甲氧苄啶与二氢叶酸还原酶（DHFR）结合，从而抑制二氢叶酸（DHF）还原为四氢叶酸（THF），从而产生抗菌作用。新诺明通过阻止对氨基苯甲酸向辅酶二氢叶酸的转化来干扰敏感微生物中核酸的合成。这些作用的最终结果是抑制胸腺嘧啶核苷的合成，从而阻止细菌 DNA 的合成。
包装
1ml
制备说明
使用甲氧苄啶：磺胺甲恶唑的 1：5 混合物制备
其他说明
保存于密闭容器内，置于干燥通风处。
警示用语：
Warning
危险声明
危险分类
Aquatic Chronic 3 - Repr. 2
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
H Abolhassani et al.
Journal of investigational allergology & clinical immunology, 23(5), 323-329 (2013-11-23)
Autoimmune disorders occur with a higher incidence in common variable immunodeficiency (CVID) patients than in the general population. To describe the clinical features of the autoimmune phenotype in patients with CVID. The hospital records of all diagnosed CVID patients referred
Osama M Sarhan et al.
Urology, 82(6), 1405-1409 (2013-10-22)
To evaluate the prognostic role of antenatal diagnosis of posterior urethral valves (PUVs) on ultimate renal function. Between 1990 and 2010, 315 patients with PUVs were diagnosed and treated at 2 separate tertiary centers. Primary valve ablation was performed in
MMWR. Morbidity and mortality weekly report, 62(46), 914-916 (2013-11-22)
In March 2012, a Salvadoran-American boy aged 7 years living in Maryland developed three slightly painful, well-demarcated, flat, gray-brown patches on his torso. A dermatologist in Washington, DC, suspected a fixed drug eruption (an erythema multiforme-like adverse drug reaction that
Escherichia coli resistant to quinolones in a neonatal unit.
Ruiz Del Castillo B, et al.
Journal of Medical Microbiology, 60, 1713-1716 (2011)
Lise Denoeud-Ndam et al.
Journal of acquired immune deficiency syndromes (1999), 65(2), 198-206 (2013-11-14)
Malaria during pregnancy has serious consequences that are worsened by HIV infection. Malaria preventive measures for HIV-infected pregnant women include cotrimoxazole (CTX) prophylaxis given to prevent HIV-related opportunistic infections and also protective against malaria, or intermittent preventive treatment (IPTp) with
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