A2487
磺胺甲恶唑，成品溶液
Ready Made Solution, 100 mg/mL in DMSO
别名:
复方新诺明, TMP-SMX
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关于此项目
经验公式（希尔记法）:
C14H18N4O3 · 5 C10H11N3O3S
化学文摘社编号:
分子量:
1556.71
MDL number:
UNSPSC Code:
51102829
NACRES:
NA.85
SMILES string
[S](=O)(=O)(Nc4n[o]c(c4)C)c3ccc(cc3)N.Nc1nc(c(cn1)Cc2cc(c(c(c2)OC)OC)OC)N
InChI
1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)
InChI key
WZRJTRPJURQBRM-UHFFFAOYSA-N
Quality Level
form
liquid, ready-to-use solution
concentration
100 mg/mL in DMSO
color
colorless to faint yellow
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, fungi, parasites
mode of action
DNA synthesis | interferes
shipped in
dry ice
storage temp.
−20°C
Application
复方新诺明已被用作抗菌剂。
Biochem/physiol Actions
复方新诺明是甲氧苄啶和磺胺甲恶唑的组合，可通过阻止核苷酸的生物合成来干扰叶酸在细菌细胞中的细胞代谢。甲氧苄啶与二氢叶酸还原酶（DHFR）结合，从而抑制二氢叶酸（DHF）还原为四氢叶酸（THF），从而产生抗菌作用。新诺明通过阻止对氨基苯甲酸向辅酶二氢叶酸的转化来干扰敏感微生物中核酸的合成。这些作用的最终结果是抑制胸腺嘧啶核苷的合成，从而阻止细菌 DNA 的合成。
Packaging
1ml
Preparation Note
使用甲氧苄啶：磺胺甲恶唑的 1：5 混合物制备
Other Notes
保存于密闭容器内，置于干燥通风处。
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 3 - Repr. 2
存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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