A255
A-77636 hydrochloride hydrate
≥98% (HPLC), solid
别名:
(−)-(1R,3S)-3-Adamantyl-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride hydrate
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关于此项目
经验公式（希尔记法）:
C20H27NO3 · HCl · xH2O
化学文摘社编号:
分子量:
365.89 (anhydrous basis)
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
solid
储存条件
desiccated
protect from light
颜色
white to off-white
溶解性
H2O: >10 mg/mL
储存温度
−20°C
SMILES字符串
O.Cl.NC[C@@H]1O[C@@H](Cc2c(O)c(O)ccc12)C34CC5CC(CC(C5)C3)C4
InChI
1S/C20H27NO3.ClH.H2O/c21-10-17-14-1-2-16(22)19(23)15(14)6-18(24-17)20-7-11-3-12(8-20)5-13(4-11)9-20;;/h1-2,11-13,17-18,22-23H,3-10,21H2;1H;1H2/t11?,12?,13?,17-,18-,20?;;/m0../s1
InChI key
KNACNUUSUYTFDY-LIWDBWMRSA-N
基因信息
human ... DRD1(1812)
相关类别
生化/生理作用
Potent, orally active D1 dopamine receptor agonist.
特点和优势
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
法律信息
Manufactured and sold under exclusive license from Abbott Laboratories.
免责声明
Hygroscopic, photosensitive, and oxygen-sensitive. Solutions should be freshly prepared.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
J X Cai et al.
The Journal of pharmacology and experimental therapeutics, 283(1), 183-189 (1997-10-23)
With advancing age, monkeys develop deficits in spatial working memory resembling those induced by lesions of the prefrontal cortex (PFC). Aged monkeys also exhibit marked loss of dopamine from the PFC, a transmitter known to be important for proper PFC
Amy F T Arnsten et al.
Biological psychiatry, 57(11), 1377-1384 (2005-06-14)
The prefrontal cortex guides behaviors, thoughts, and feelings using representational knowledge, i.e., working memory. These fundamental cognitive abilities subserve the so-called executive functions: the ability to inhibit inappropriate behaviors and thoughts, regulate our attention, monitor our actions, and plan and
Allison L Chausmer et al.
Psychopharmacology, 159(2), 145-153 (2002-02-28)
Recent data suggest that dopamine (DA) D1-like receptor full agonists may be potential pharmacotherapeutic agents for treating cocaine abuse. The structurally novel isochroman D1-like agonist, A-77636, has not been well characterized and may prove to be useful as such an
E Acquas et al.
Psychopharmacology, 125(2), 162-167 (1996-05-01)
The effects of chronic lithium treatment on methylphenidate-, D1 dopamine receptor agonist (A-77636)-, and tactile stimulation-induced increases in frontal cortical acetylcholine release were studied in the rat using in vivo brain microdialysis. Cortical acetylcholine release in control rats was maximally
Vera Bubenikova-Valesova et al.
The international journal of neuropsychopharmacology, 12(7), 873-883 (2009-01-22)
Cognitive impairment has been found across all subtypes of schizophrenia. The location and function of dopamine-1 receptors (D1Rs) make them attractive targets for the treatment of cognitive impairment in schizophrenia. Here we investigate the systemic effect of a D1R agonist
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