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安全信息

A255

Sigma-Aldrich

A-77636 hydrochloride hydrate

≥98% (HPLC), solid

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别名:
(−)-(1R,3S)-3-Adamantyl-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride hydrate
经验公式（希尔记法）:
C20H27NO3 · HCl · xH2O
CAS号:
145307-34-2
分子量:
365.89 (anhydrous basis)
PubChem化学物质编号:
24277883
NACRES:
NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

solid

储存条件

desiccated
protect from light

颜色

white to off-white

溶解性

H2O: >10 mg/mL

储存温度

−20°C

SMILES字符串

O.Cl.NC[C@@H]1O[C@@H](Cc2c(O)c(O)ccc12)C34CC5CC(CC(C5)C3)C4

InChI

1S/C20H27NO3.ClH.H2O/c21-10-17-14-1-2-16(22)19(23)15(14)6-18(24-17)20-7-11-3-12(8-20)5-13(4-11)9-20;;/h1-2,11-13,17-18,22-23H,3-10,21H2;1H;1H2/t11?,12?,13?,17-,18-,20?;;/m0../s1

InChI key

KNACNUUSUYTFDY-LIWDBWMRSA-N

基因信息

human ... DRD1(1812)

生化/生理作用

Potent, orally active D1 dopamine receptor agonist.

特点和优势

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

注意

Hygroscopic, photosensitive, and oxygen-sensitive. Solutions should be freshly prepared.

法律信息

Manufactured and sold under exclusive license from Abbott Laboratories.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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Sanjida S Saklayen et al.
The Journal of pharmacology and experimental therapeutics, 311(1), 342-348 (2004-06-04)
The nigrostriatal dopamine system of the mammalian brain is necessary for normal voluntary motor activity. Dopamine exerts its effects by acting on two primary receptor subtypes: D1-like (D1 and D5) and D2-like (D2, D3, and D4) receptors. Previous research has
Allison L Chausmer et al.
Psychopharmacology, 159(2), 145-153 (2002-02-28)
Recent data suggest that dopamine (DA) D1-like receptor full agonists may be potential pharmacotherapeutic agents for treating cocaine abuse. The structurally novel isochroman D1-like agonist, A-77636, has not been well characterized and may prove to be useful as such an
Vera Bubenikova-Valesova et al.
The international journal of neuropsychopharmacology, 12(7), 873-883 (2009-01-22)
Cognitive impairment has been found across all subtypes of schizophrenia. The location and function of dopamine-1 receptors (D1Rs) make them attractive targets for the treatment of cognitive impairment in schizophrenia. Here we investigate the systemic effect of a D1R agonist
E Acquas et al.
Psychopharmacology, 125(2), 162-167 (1996-05-01)
The effects of chronic lithium treatment on methylphenidate-, D1 dopamine receptor agonist (A-77636)-, and tactile stimulation-induced increases in frontal cortical acetylcholine release were studied in the rat using in vivo brain microdialysis. Cortical acetylcholine release in control rats was maximally
Amy F T Arnsten et al.
Biological psychiatry, 57(11), 1377-1384 (2005-06-14)
The prefrontal cortex guides behaviors, thoughts, and feelings using representational knowledge, i.e., working memory. These fundamental cognitive abilities subserve the so-called executive functions: the ability to inhibit inappropriate behaviors and thoughts, regulate our attention, monitor our actions, and plan and
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