A2559
N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide
≥97% (HPLC), powder
别名:
Ac-DEVD-pNA
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关于此项目
经验公式（希尔记法）:
C26H34N6O13
化学文摘社编号:
分子量:
638.58
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.32
质量水平
方案
≥97% (HPLC)
表单
powder
颜色
white
储存温度
−20°C
SMILES字符串
CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc(cc1)[N+]([O-])=O
InChI
1S/C26H34N6O13/c1-12(2)22(26(43)30-18(11-21(38)39)24(41)28-14-4-6-15(7-5-14)32(44)45)31-23(40)16(8-9-19(34)35)29-25(42)17(10-20(36)37)27-13(3)33/h4-7,12,16-18,22H,8-11H2,1-3H3,(H,27,33)(H,28,41)(H,29,42)(H,30,43)(H,31,40)(H,34,35)(H,36,37)(H,38,39)/t16-,17-,18-,22-/m0/s1
InChI key
GGXRLUDNGFFUKI-ORGXJRBJSA-N
基因信息
human ... CASP3(836)
Amino Acid Sequence
NAc-Asp-Glu-Val-Asp-pNA
应用
N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide has been used as a chromogenic substrates for determining caspase-3 and caspase-8 activities in liver tissue homogenates and caspase 3 activity in aortic vascular smooth muscle cells and neuroblastoma cell lines.
生化/生理作用
Colorimetric substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Hui-Fang Jin et al.
Frontiers in cell and developmental biology, 8, 555937-555937 (2020-10-20)
MicroRNAs (miRNAs) are dysregulated in the context of many cancer types, making them potentially ideal diagnostic or therapeutic targets in patients in which they are aberrantly expressed. In the present study, we found miR-7 to be downregulated in gastric cancer
Xiangyu Wang et al.
Frontiers in cellular and infection microbiology, 7, 410-410 (2017-10-07)
Enterohemorrhagic
Human cytomegalovirus immediate early protein 2 enhances myocardin-mediated survival of rat aortic smooth muscle cells.
Liao XH, et al.
Virus Research, 192(2), 85-91 (2014)
Familial CJD associated PrP mutants within transmembrane region induced Ctm-PrP retention in ER and triggered apoptosis by ER stress in SH-SY5Y cells.
Wang X, et al.
PLoS ONE, 6(1), e14602-e14602 (2011)
Nrf2 protects against 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative injury and steatohepatitis.
Lu H, et al.
Toxicology and Applied Pharmacology, 256(2), 122-135 (2011)
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