A2580
血管紧张素转换酶 来源于猪肾脏
lyophilized powder, ≥10 units/mg protein (Bradford)
别名:
肽基二肽酶A, 酸性酯酶
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
Specific activity:
≥10 units/mg protein (Bradford)
产品名称
血管紧张素转换酶 来源于猪肾脏, lyophilized powder, ≥10 units/mg protein (Bradford)
form
lyophilized powder
specific activity
≥10 units/mg protein (Bradford)
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Quality Level
Gene Information
pig ... ACE(613133)
Application
猪肾血管紧张素转化酶已用于体外血管紧张素转化酶（ACE）抑制试验。
Biochem/physiol Actions
从敏感底物（如血管紧张素I和缓激肽）中去除C末端二肽。
血管紧张素转换酶（ACE）催化血管紧张素I转化为血管紧张素II，调节水电解质平衡和体循环血压。ACE抑制血管舒张剂缓激肽。ACE抑制剂用于治疗高血压。
General description
ACE是一种单体，分子量约为170 kDa
活性pH值范围：7-8.5
最佳温度：37°C
活性需要锌
抑制剂：卡托普利、依那普利拉、赖诺普利等。（1-10μM）
活性pH值范围：7-8.5
最佳温度：37°C
活性需要锌
抑制剂：卡托普利、依那普利拉、赖诺普利等。（1-10μM）
血管紧张素转化酶（ACE）由mRNA脱帽酶亚单位1（DCP1）基因编码。其是一种属于M2家族的锌金属蛋白酶。
Other Notes
在pH为8.3，温度为37°C的条件下，在50mM HEPES和300mM NaCl中，一个单位每分钟可将1.0μmol/ min的马尿酰组氨酰亮氨酸转化成马尿酸。
Physical form
含Tris缓冲盐的冻干粉
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
低风险生物材料
此项目有
Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial
Hansson L, et al.
Lancet, 353(9153), 611-616 (1999)
Sequence variation in the human angiotensin converting enzyme
Rieder MJ, et al.
Nature Genetics, 22(1), 59-59 (1999)
Liang Xiao et al.
American journal of physiology. Cell physiology, 304(11), C1073-C1079 (2013-03-29)
Brain ANG II plays an important role in modulating sympathetic function and homeostasis. The generation and degradation of ANG II are carried out, to a large extent, through the angiotensin-converting enzyme (ACE) and ACE2, respectively. In disease states, such as
N M Hooper et al.
The Biochemical journal, 241(3), 625-633 (1987-02-01)
Peptidyl-dipeptidase A (angiotensin converting enzyme; ACE, EC 3.4.15.1), has been purified from pig kidney and striatum by affinity chromatography employing the selective inhibitor lisinopril as ligand. The inclusion of a 2.8 nm spacer arm improved the yield of the enzyme
Letter by Tsuda regarding article, "Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging".
Kazushi Tsuda
Stroke, 44(4), e34-e34 (2013-03-07)
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