A2612
亚细亚酸
≥98% (HPLC), from Centella asiatica
别名:
2α, 23-二羟基熊果酸, NSC 166063, 达玛醇酸
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关于此项目
经验公式（希尔记法）:
C30H48O5
化学文摘社编号:
分子量:
488.70
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352212
EC Number:
482-720-9
MDL number:
biological source
Centella asiatica
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
white
mp
325-330 °C (lit.)
solubility
methanol: 1 mg/mL, clear, colorless
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
SMILES string
C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O
InChI
1S/C30H48O5/c1-17-9-12-30(25(34)35)14-13-28(5)19(23(30)18(17)2)7-8-22-26(3)15-20(32)24(33)27(4,16-31)21(26)10-11-29(22,28)6/h7,17-18,20-24,31-33H,8-16H2,1-6H3,(H,34,35)/t17-,18+,20-,21-,22-,23+,24+,26+,27+,28-,29-,30+/m1/s1
InChI key
JXSVIVRDWWRQRT-UYDOISQJSA-N
General description
积雪草酸是一种天然存在的五环三萜，来源于积雪草。
Application
积雪草酸已被用于考察其在胶质母细胞瘤细胞中细胞毒性潜力的 体外研究。 它也被用于积雪草中积雪草酸的体外定量分析以及以有机刺激剂增加积雪草酸产量的 体外研究。
积雪草酸衍生物合成的起始物料：
- 抗癌药
- 糖原磷酸化酶抑制剂
- 肝保护剂
Biochem/physiol Actions
据报道积雪草酸对胶质母细胞瘤、乳腺、肝脏、黑素瘤和结肠癌有毒害作用，并具有抗血管生成活性。此外，它可穿过血脑屏障，并导致人恶性胶质瘤和肝细胞瘤的细胞凋亡。积雪草酸也有效抑制紫外线A调节的信号转导通路，因此可用于防止紫外线A诱导的皮肤光老化。它具有抗伤痛和抗炎特性，对于β-淀粉样蛋白和谷氨酸酯诱导的神经毒性有抑制作用。
积雪草酸常用于伤口愈合。积雪草酸具有抗氧化、抗炎和神经保护属性
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存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Byung Chul Park et al.
Cancer letters, 218(1), 81-90 (2005-01-11)
Asiatic acid (AA) is a pentacyclic triterpene found in Centella asiatica. In the present study, the mechanism of anticancer effect of AA on skin cancer was investigated. AA decreased viability and induced apoptosis in human melanoma SK-MEL-2 cells in a
Quantification of asiatic acid from plant parts of Centella asiatica L. and enhancement of its synthesis through organic elicitors in in vitro
Mohammadparast B, et al.,
Horticulture, Environment, and Biotechnology, 55(6), 578-582 (2014)
Flourina Kumar Thakor et al.
Molecular and cellular biochemistry, 430(1-2), 179-190 (2017-02-17)
Glioblastoma multiforme is the most common and malignant primary brain tumor in adults. Despite current treatment options including surgery followed by radiation and chemotherapy with temozolomide and cisplatin, the median survival rate remains low (<16 months). Combined with increasing drug
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A2612-50MG | 04061833046814 |
| A2612-10MG | 04061833359402 |