A2647
腺苷5′-(β,γ-酰亚胺)三磷酸盐 锂盐 水合物
≥93% (HPLC), natural (organic), powder
别名:
β,γ-硫代腺苷5′-三磷酸盐 锂盐 水合物, AMP-PNP, ATP[β,γ-NH], App(NH)p, 腺苷酰亚胺二磷酸 锂盐 水合物
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5 MG
¥1,213.68
25 MG
¥4,381.16
100 MG
¥13,962.73
关于此项目
经验公式（希尔记法）:
C10H17N6O12P3 · xLi+ · yH2O
化学文摘社编号:
分子量:
506.20 (free acid basis)
Beilstein:
6047109
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
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产品名称
腺苷5′-(β,γ-酰亚胺)三磷酸盐 锂盐 水合物, ≥93% (HPLC), powder
生物来源
natural (organic)
质量水平
方案
≥93% (HPLC)
表单
powder
颜色
white
溶解性
H2O: 50 mg/mL
运输
dry ice
储存温度
−20°C
SMILES字符串
[Li+].[Li+].[Li+].[Li+].[H]O[H].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)NP([O-])([O-])=O)[C@@H](O)[C@H]3O
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此商品 | A1388 | M3763 | G0635 |
|---|---|---|---|
| biological source natural (organic) | biological source synthetic (organic) | biological source synthetic (organic) | biological source synthetic (organic) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| assay ≥93% (HPLC) | assay ≥75% (HPLC) | assay ≥99% (HPLC) | assay ≥85% (HPLC) |
| form powder | form powder | form powder | form powder |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −70°C |
| solubility H2O: 50 mg/mL | solubility H2O: 25 mg/mL | solubility water: 50 mg/mL, clear, colorless | solubility H2O: 50 mg/mL |
![鸟苷5′-[β,γ-亚氨基]三磷酸 三钠盐 水合物 ≥85% (HPLC), powder](/deepweb/assets/sigmaaldrich/product/structures/204/494/05808804-1ca7-44bf-b6c5-d4934dc7cb85/640/05808804-1ca7-44bf-b6c5-d4934dc7cb85.png)
应用
腺苷5′-(β,γ--酰亚胺)三磷酸锂盐水合物用于研究单价阳离子Li+、Na+、K+、NH4+、Rb+ 和Cs+对于核酸组分固体和溶液结构的影响。腺苷5′-(β,γ-酰亚胺)三磷酸锂盐水合物被用来确定抗抑郁药抑制干扰素-γ-诱导的小胶质细胞产生的IL-6和一氧化氮。
生化/生理作用
一种非水解性ATP类似物。AMP-PNP竞争性抑制基于ATP的酶系统，比如谷氨酰胺合成酶。它可抑制一系列需要水解ATP的酶，比如DNA拓扑异构酶Ⅱ，SV40大T抗原螺旋酶和一系列激酶。阻断ATP敏感钙依赖性钾离子通道。
制备说明
可以制作10mg/mL储备溶液，分装，保存在-70℃，最多可以3个月。
免责声明
AMP-PNP在酸性条件非常不稳定，快速水解成磷酸酰胺和无机磷酸盐。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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