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A2647

Sigma-Aldrich

腺苷5′-(β,γ-酰亚胺)三磷酸盐 锂盐 水合物

≥93% (HPLC), powder

别名:

β,γ-硫代腺苷5′-三磷酸盐 锂盐 水合物, AMP-PNP, ATP[β,γ-NH], App(NH)p, 腺苷酰亚胺二磷酸 锂盐 水合物

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5 MG
¥1,213.68
25 MG
¥4,381.16
100 MG
¥13,962.73

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5 MG
¥1,213.68
25 MG
¥4,381.16
100 MG
¥13,962.73

About This Item

经验公式（希尔记法）:
C10H17N6O12P3 · xLi+ · yH2O
CAS Number:
25612-73-1
分子量:
506.20 (free acid basis)
Beilstein:
6047109
MDL编号:
MFCD03424105
UNSPSC代码:
41106305
PubChem化学物质编号:
24890685
NACRES:
NA.51

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生物来源

natural (organic)

方案

≥93% (HPLC)

表单

powder

颜色

white

溶解性

H2O: 50 mg/mL

运输

dry ice

储存温度

−20°C

SMILES字符串

[Li+].[Li+].[Li+].[Li+].[H]O[H].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)NP([O-])([O-])=O)[C@@H](O)[C@H]3O

InChI

1S/C10H17N6O12P3/c11-8-5-9(13-2-12-8)16(3-14-5)10-7(18)6(17)4(27-10)1-26-31(24,25)28-30(22,23)15-29(19,20)21/h2-4,6-7,10,17-18H,1H2,(H,24,25)(H2,11,12,13)(H4,15,19,20,21,22,23)/t4-,6-,7-,10-/m1/s1

InChI key

PVKSNHVPLWYQGJ-KQYNXXCUSA-N

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此商品
A1388M3763G0635
腺苷5′-(β,γ-酰亚胺)三磷酸盐 锂盐 水合物 ≥93% (HPLC), powder

A2647

腺苷5′-(β,γ-酰亚胺)三磷酸盐 锂盐 水合物

腺苷5′-[γ-硫代]三磷酸盐 四锂盐 ≥75% (HPLC), powder

A1388

腺苷5′-[γ-硫代]三磷酸盐 四锂盐

腺苷 5′ -（α，β-亚甲基）二磷酸 ADP analog

M3763

腺苷 5′ -（α，β-亚甲基）二磷酸

鸟苷5′-[β,γ-亚氨基]三磷酸 三钠盐 水合物 ≥85% (HPLC), powder

G0635

鸟苷5′-[β,γ-亚氨基]三磷酸 三钠盐 水合物

biological source

natural (organic)

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

synthetic (organic)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

assay

≥93% (HPLC)

assay

≥75% (HPLC)

assay

≥99% (HPLC)

assay

≥85% (HPLC)

solubility

H2O: 50 mg/mL

solubility

H2O: 25 mg/mL

solubility

water: 50 mg/mL, clear, colorless

solubility

H2O: 50 mg/mL

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−70°C

应用

腺苷5′-(β,γ--酰亚胺)三磷酸锂盐水合物用于研究单价阳离子Li+、Na+、K+、NH4+、Rb+ 和Cs+对于核酸组分固体和溶液结构的影响。腺苷5′-(β,γ-酰亚胺)三磷酸锂盐水合物被用来确定抗抑郁药抑制干扰素-γ-诱导的小胶质细胞产生的IL-6和一氧化氮。

生化/生理作用

一种非水解性ATP类似物。AMP-PNP竞争性抑制基于ATP的酶系统，比如谷氨酰胺合成酶。它可抑制一系列需要水解ATP的酶，比如DNA拓扑异构酶Ⅱ，SV40大T抗原螺旋酶和一系列激酶。阻断ATP敏感钙依赖性钾离子通道。

注意

AMP-PNP在酸性条件非常不稳定，快速水解成磷酸酰胺和无机磷酸盐。

重悬

可以制作10mg/mL储备溶液，分装，保存在-70℃，最多可以3个月。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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    分析证书(COA)

    Lot/Batch Number
    0000453683
    0000453682
    0000453682
    0000453683
    SLCM9268

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