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线性分子式:
(CH3)3N+CH2CH2OCOCH3Cl-
化学文摘社编号:
分子量:
181.66
NACRES:
NA.75
PubChem Substance ID:
eCl@ss:
32190102
UNSPSC Code:
12352209
EC Number:
200-468-8
MDL number:
Beilstein/REAXYS Number:
3571875
Biological source:
synthetic
Form:
powder
Assay:
~99%
InChI key
JUGOREOARAHOCO-UHFFFAOYSA-M
InChI
1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
SMILES string
[Cl-].CC(=O)OCC[N+](C)(C)C
biological source
synthetic
assay
~99%
form
powder
technique(s)
cell culture | mammalian: suitable
mp
146-150 °C (lit.)
solubility
water: 100 mg/mL, clear, colorless
shipped in
ambient
storage temp.
room temp
Quality Level
Gene Information
human ... CHRM3(1131)
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Application
氯化乙酰胆碱已用于制备乙酰胆碱,是乙酰胆碱(ACh)离子导入的常用溶媒。它还用于处理aNS-1来源神经元以进行cAMP(环腺苷单磷酸)分析,也用于检测其对G蛋白偶联受体(GPCR)的影响作用。
Biochem/physiol Actions
氯化乙酰胆碱,20mg/kg体重注射,减少小鼠实验性诱发脓毒病的死亡和血浆促炎细胞因子。类胆碱能抗-炎症机制可能通过乙酰胆碱和 α7n单核细胞,巨噬细胞和中性粒细胞上的胆红素受体互作接待,降低了促炎细胞活素,比如 TNF-α,IL-1β,和IL-6。
胆碱能突触中的内源性神经递质,通过增强肌膜动作电位来触发肌肉收缩反应。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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