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A2731

AMG 9810

≥98% (HPLC), powder

别名:

2E-N-(2,3-二氢-1,4-苯并二恶英-6-基)-3-[4-(1,1-二甲基乙基)苯基]-2-丙酰胺

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关于此项目

经验公式（希尔记法）:
C21H23NO3
化学文摘社编号:
545395-94-6
分子量:
337.41
NACRES:
NA.77
PubChem Substance ID:
329770793
UNSPSC Code:
12352203
MDL number:
MFCD00955103
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >5 mg/mL

originator

Amgen

storage temp.

2-8°C

SMILES string

CC(C)(C)c1ccc(\C=C\C(=O)Nc2ccc3OCCOc3c2)cc1

InChI

1S/C21H23NO3/c1-21(2,3)16-7-4-15(5-8-16)6-11-20(23)22-17-9-10-18-19(14-17)25-13-12-24-18/h4-11,14H,12-13H2,1-3H3,(H,22,23)/b11-6+

InChI key

GZTFUVZVLYUPRG-IZZDOVSWSA-N

Biochem/physiol Actions

AMG 9810是一种肉桂酰胺TRPV1（类香草醇受体1）拮抗剂，在辣椒碱刺激的动物模型中，可以防止由辣椒素刺激的擦眼行为，并且可以逆转痛觉过敏。它具有抗痛觉过敏特性。
AMG 9810是TRPV1受体的有效非香草醛拮抗剂。IC50 = 17 nM。

Features and Benefits

该化合物由Amgen开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H413

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000407211
0000407211
0000086682
0000067578
0000043882

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全球贸易项目编号

货号GTIN
A2731-10MG04061833359716
A2731-50MG04061833217320