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此商品 | PHR1783 | Z0153 | BM0030 |
---|---|---|---|
form solid | form - | form powder | form powder |
assay ≥98% (HPLC) | assay - | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
Quality Level 100 | Quality Level 300 | Quality Level 100 | Quality Level 100 |
storage temp. room temp | storage temp. 2-30°C | storage temp. room temp | storage temp. room temp |
solubility DMSO: 40 mg/mL | solubility - | solubility DMSO: >15 mg/mL | solubility DMSO: 20 mg/mL, clear |
originator AstraZeneca | originator - | originator - | originator - |
应用
生化/生理作用
芳香化酶可将肾上腺雄激素转化为雌激素;这种酶活性是绝经后妇女雌激素的主要产生来源。 绝经后妇女雌激素受体阳性乳腺癌的一种治疗方法便是通过抑制芳香化酶。 阿那曲唑是一种非甾体苄基三唑衍生物,可通过竞争性抑制而对芳香化酶进行抑制,并用于治疗雌激素受体阳性的乳腺癌。[6] 该化合物被认为是第三代II型芳香化酶抑制剂,因其与第一代、第二代抑制剂相比,针对其他甾体激素具有更强的选择性和更低的作用(如有)。[7]
阿那曲唑是一种非甾体芳香酶抑制剂。
特点和优势
该化合物由AstraZeneca开发。要浏览其他药物开发化合物和批准的药物/候选药物列表,单击此处。
警示用语:
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Repr. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Anastrozole Reduce Cell Proliferation and Induce Apoptosis in Glioblastoma Multiforme Xenograft Mouse Model
Aguilar G, et al.
Journal of Cancer Science & Therapy, 9(3), 655-660 (2017)
Extra virgin olive oil potentiates the effects of aromatase inhibitors via glutathione depletion in estrogen receptor-positive human breast cancer (MCF-7) cells
Ismail AM, et al.
Food And Chemical Toxicology, 62(3), 817-824 (2013)
Irene Guadalupe Aguilar-García et al.
Brain sciences, 13(3) (2023-03-30)
Glioblastoma Multiforme (GBM) is a tumor that infiltrates several brain structures. GBM is associated with abnormal motor activities resulting in impaired mobility, producing a loss of functional motor independence. We used a GBM xenograft implanted in the striatum to analyze
Dennis C Sgroi et al.
The Lancet. Oncology, 14(11), 1067-1076 (2013-09-17)
Biomarkers to improve the risk-benefit of extended adjuvant endocrine therapy for late recurrence in patients with oestrogen-receptor-positive breast cancer would be clinically valuable. We compared the prognostic ability of the breast-cancer index (BCI) assay, 21-gene recurrence score (Oncotype DX), and
Kutlwano R Xulu et al.
International journal of molecular sciences, 22(8) (2021-05-01)
Thromboembolic complications are a leading cause of morbidity and mortality in cancer patients. Cancer patients often present with an increased risk for thrombosis including hypercoagulation, so the application of antiplatelet strategies to oncology warrants further investigation. This study investigated the
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