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A2861

阿司咪唑

Name: 阿司咪唑
Brand: SIGMA

≥98% (HPLC), hERG potassium channel blocker, powder

别名:

1-（4-氟苄基）-2-（1-[4-甲氧基苯乙基] 哌啶-4-基）氨基苯并咪唑

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关于此项目

经验公式（希尔记法）:

C₂₈H₃₁FN₄O

化学文摘社编号:

68844-77-9

分子量:

458.57

NACRES:

NA.77

PubChem Substance ID:

329770802

UNSPSC Code:

41121800

EC Number:

272-441-9

MDL number:

MFCD00153919

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated, protect from light

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属性

产品名称

阿司咪唑, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated, protect from light

solubility

DMSO: >20 mg/mL

originator

Johnson & Johnson

storage temp.

2-8°C

SMILES string

COc1ccc(CCN2CCC(CC2)Nc3nc4ccccc4n3Cc5ccc(F)cc5)cc1

InChI

1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31)

InChI key

GXDALQBWZGODGZ-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

说明

Biochem/physiol Actions

阿司咪唑是一种强效 hERG 钾通道阻断剂（IC ₅₀ 为 0.9 nM），可用作药理学分子伴侣，以纠正折叠缺陷并恢复一些 hERG 通道突变形式的蛋白功能。它还被研究用于治疗疟疾、癌症中的 hERG 和 hEAG 通道功能以及作为第二代抗组胺药 H-1 拮抗剂。

阿司咪唑是一种强效 hERG 钾通道阻滞剂（IC ₅₀ 为 0.9 nM）。

Features and Benefits

该化合物在受体分类和信号转导手册的钾通道页面上有重点介绍。想要浏览手册的其他页面，请单击此处。

该化合物由 Johnson & Johnson 开发。如需浏览其他制药公司开发的化合物和批准的药物/候选药物列表，请点击此处。

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000512177

0000499943

0000451522

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商品

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全球贸易项目编号

货号	GTIN
A2861-50MG	04061833359839
A2861-10MG	04061833359822