A2979
A-317491 钠盐 水合物
≥98% (HPLC), powder
别名:
55-[[[（3-苯氧基苯基）甲基] \ [(1S)-1,2,3,4-四氢-1-萘基] 氨基] 羰基]-1,2,4-苯四甲酸 钠盐 水合物
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关于此项目
经验公式（希尔记法）:
C33H27NO8 · xNa+ · yH2O
分子量:
565.57 (anhydrous free acid basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
产品名称
A-317491 钠盐 水合物, ≥98% (HPLC), powder
SMILES string
[Na].[H]O[H].OC(=O)c1cc(C(O)=O)c(cc1C(O)=O)C(=O)N(Cc2cccc(Oc3ccccc3)c2)[C@H]4CCCc5ccccc45
InChI
1S/C33H27NO8.Na.H2O.H/c35-30(25-17-27(32(38)39)28(33(40)41)18-26(25)31(36)37)34(29-15-7-10-21-9-4-5-14-24(21)29)19-20-8-6-13-23(16-20)42-22-11-2-1-3-12-22;;;/h1-6,8-9,11-14,16-18,29H,7,10,15,19H2,(H,36,37)(H,38,39)(H,40,41);;1H2;/t29-;;;/m0.../s1
InChI key
VEMCGHRDAPMXLI-VYEUTZPBSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 15 mg/mL, clear
originator
Abbott
Quality Level
Application
A-317491钠盐水合物已被用来阻止P2X3受体。它也被用来阻止增加的膜电导。
Biochem/physiol Actions
A-317491 通过抑制 P2X3 受体介导的 Ca 2 + 内流，有助于减轻神经性和炎性疼痛。
新型 P2X 3 和 P2X 2/3 受体拮抗剂
Features and Benefits
该化合物的相关信息整理于受体分类和信号转导手册的 P2受体：P2X离子通道家族 页面。欲浏览其他手册页面，请 点击这里。
Legal Information
依照美国专利号 6,831,193。在Abbott Laboratories 的许可下销售
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Early life allergen-induced mucus overproduction requires augmented neural stimulation of pulmonary neuroendocrine cell secretion
Barrios J, et al.
Faseb Journal, 31(9), 4117-4128 (2017)
Michael F Jarvis et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(26), 17179-17184 (2002-12-17)
P2X3 and P2X2/3 receptors are highly localized on peripheral and central processes of sensory afferent nerves, and activation of these channels contributes to the pronociceptive effects of ATP. A-317491 is a novel non-nucleotide antagonist of P2X3 and P2X2/3 receptor activation.
Michael F Jarvis et al.
The Journal of pharmacology and experimental therapeutics, 310(1), 407-416 (2004-03-17)
A-317491 is a potent and selective antagonist of P2X3 and P2X(2/3) receptors. In the present studies, the ability of [3H]A-317491 to label recombinant human P2X(2/3) and P2X(3) receptors was characterized. Using membranes prepared from 1321N1 cells expressing P2X(2/3) receptors, [3H]A-317491
Effect of A-317491 delivered by glycolipid-like polymer micelles on endometriosis pain
Yuan M, et al.
International journal of nanomedicine, 12, 8171-8171 (2017)
Electrophysiological Evidence for Functional Astrocytic P2X3 Receptors in the Mouse Trigeminal Caudal Nucleus
Lee J, et al.
Experimental Neurobiology, 27(2), 88-93 (2018)
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