A3010
酰基酶Ⅰ 来源于猪肾脏
Grade I, lyophilized powder, ≥1500 units/mg protein
别名:
N-酰基氨基酸酰胺水解酶, 氨基酰化酶
产品名称
酰基酶Ⅰ 来源于猪肾脏, Grade I, lyophilized powder, ≥1500 units/mg protein
type
Grade I
form
lyophilized powder
specific activity
≥1500 units/mg protein
composition
Protein, ≥60%
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
pig ... ACY1(396930)
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Analysis Note
缩二脲法测定蛋白
Application
猪肾中的酰化酶 I 已被用于研究各种 S-烷基-N-乙酰基-L-半胱氨酸及其碳、氧类似物的酰化酶 I 催化的脱乙酰作用 。酰化酶 I 可能有助于催化 N-乙酰氨基酸生成对映体纯的 L-氨基酸 。
Biochem/physiol Actions
酰化酶 I 催化 N-乙酰基-L-半胱氨酸和 S-烷基-N-乙酰基-L-半胱氨酸的脱乙酰化。正丁基丙二酸是酰化酶 Ⅰ 的抑制剂。S-烷基-N-乙酰基-L-半胱氨酸与短 (C0-C3) 和不分枝 S-烷基取代已被发现是良好的酰化酶 I 底物。
Other Notes
一个单元将在pH 7.0 和 25°C 条件下每小时水解 1.0μmol N-乙酰- L -蛋氨酸。
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
低风险生物材料
动植物源性产品
此项目有
Debby Ngo et al.
JCI insight, 6(5) (2021-02-17)
Recent advances in proteomic technologies have made high-throughput profiling of low-abundance proteins in large epidemiological cohorts increasingly feasible. We investigated whether aptamer-based proteomic profiling could identify biomarkers associated with future development of type 2 diabetes (T2DM) beyond known risk factors.
Y Fukagawa et al.
The Journal of antibiotics, 33(6), 543-549 (1980-06-01)
PS-5 was deacetylated to NS-5 (deacetylated PS-5) by l-amino acid acylase from porcine kidney and D-amino acid acylase from Streptomyces olivaceus but not by l-amino acid acylase from Aspergillus sp. Using PS-5, N-chloroacetyl-l-phenylalanine and N-chloroacetyl-D-valine as substrates, acylase producers were
Jinit Masania et al.
Oxidative medicine and cellular longevity, 2019, 4851323-4851323 (2019-12-13)
Glycation, oxidation, nitration, and crosslinking of proteins are implicated in the pathogenic mechanisms of type 2 diabetes, cardiovascular disease, and chronic kidney disease. Related modified amino acids formed by proteolysis are excreted in urine. We quantified urinary levels of these
K Kubo et al.
The Journal of antibiotics, 33(6), 556-565 (1980-06-01)
L-Amino acid acylase and D-amino acid acylase were stable below 50 degrees C, although the D-enzyme was more thermostable than the L-enzyme at higher temperatures. At 30 degrees C they showed the highest reaction velocity in phosphate buffer of pH
V Uttamsingh et al.
Chemical research in toxicology, 11(7), 800-809 (1998-07-22)
The aminoacylase that catalyzes the hydrolysis of N-acetyl-L-cysteine (NAC) was identified as acylase I after purification by column chromatography and electrophoretic analysis. Rat kidney cytosol was fractionated by ammonium sulfate precipitation, and the proteins were separated by ion-exchange column chromatography
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