A3013
腺苷 2′(3′)-单磷酸混合异构体
别名:
酵母腺苷酸
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关于此项目
经验公式（希尔记法）:
C10H14N5O7P
化学文摘社编号:
分子量:
347.22
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
204-990-7
MDL number:
InChI key
UQRXDDDXDPEXNS-VQFZJOCSSA-N
InChI
1S/2C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(17)7(4(1-16)21-10)22-23(18,19)20;11-8-5-9(13-2-12-8)15(3-14-5)10-7(22-23(18,19)20)6(17)4(1-16)21-10/h2*2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t2*4-,6-,7-,10-/m11/s1
SMILES string
Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H]3O.Nc4ncnc5n(cnc45)[C@@H]6O[C@H](CO)[C@@H](O)[C@H]6OP(O)(O)=O
biological source
synthetic
assay
≥45% (Adenosine-3′-monophosphate, HPLC)
≥97% (Total Adenosine-3′-monophosphate; Adenosine-2′-monophosphate, HPLC)
10-55% ( Adenosine-2′-monophosphate, HPLC)
form
powder
solubility
1 M NH4OH: 50 mg/mL, clear, colorless
storage temp.
−20°C
Quality Level
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相关类别
Application
腺苷2′(3′)-单磷酸盐混合异构体被用作分离和分离的标准物定量嘌呤(腺嘌呤和鸟嘌呤)和腺嘌呤核糖核苷单磷酸盐（2’-AMP 和 3’-AMP）通过等温高性能液体色谱法 (HPLC)。它也被用来筛选多个糖结合 ATPase A (MsbA) 转运蛋白。
General description
3′-单磷酸腺苷（3′-AMP）和2′-单磷酸腺苷（2′-AMP）是由金属依赖性磷酸二酯酶家族水解2′,3′-cAMP产生的代谢产物。2′-AMP和3′-AMP通过A2B受体抑制肾小球前血管平滑肌细胞和肾小球系膜细胞的增殖。
Other Notes
不要与腺苷 2′:3′-环一磷酸混淆
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Georgina Berridge et al.
The Biochemical journal, 365(Pt 1), 295-301 (2002-04-09)
Nicotinic acid-adenine dinucleotide phosphate (NAADP) is a newly described Ca2+-mobilizing nucleotide that appears to target intracellular Ca2+-release channels distinct from those sensitive to inositol trisphosphate or ryanodine/cyclic ADP-ribose. Little, however, is known concerning the regulation of cellular NAADP levels. In
Shuji Noguchi
Protein and peptide letters, 17(12), 1559-1561 (2010-09-23)
Asparagine can be non-enzymatically deamidated and isomerized via succinimide to isoaspartate. This post-translational modification can potentially alter the physical properties or the function of the parent protein. Asn32 of ribonuclease U2A from Ustilago sphaerogena is known to rapidly deamidate and
W C Lam et al.
Biochemistry, 31(29), 6756-6760 (1992-07-28)
Phosphorescence and ODMR measurements have been made on ribonuclease T1 (RNase T1), the mutated enzyme RNase T1 (Y45W), and their complexes with 2'GMP and 2'AMP. It is not possible to observe the phosphorescence of Trp45 in RNase T1 (Y45W). Only
Andrea A Putnam et al.
Journal of molecular biology, 425(20), 3839-3845 (2013-05-25)
In eukaryotes, cellular levels of adenosine monophosphate (AMP) signal the metabolic state of the cell. AMP concentrations increase significantly upon metabolic stress, such as glucose deprivation in yeast. Here, we show that several DEAD-box RNA helicases are sensitive to AMP
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