A3013
腺苷 2′(3′)-单磷酸混合异构体
别名:
酵母腺苷酸
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关于此项目
经验公式（希尔记法）:
C10H14N5O7P
化学文摘社编号:
分子量:
347.22
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
204-990-7
MDL number:
InChI key
UQRXDDDXDPEXNS-VQFZJOCSSA-N
InChI
1S/2C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(17)7(4(1-16)21-10)22-23(18,19)20;11-8-5-9(13-2-12-8)15(3-14-5)10-7(22-23(18,19)20)6(17)4(1-16)21-10/h2*2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t2*4-,6-,7-,10-/m11/s1
SMILES string
Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H]3O.Nc4ncnc5n(cnc45)[C@@H]6O[C@H](CO)[C@@H](O)[C@H]6OP(O)(O)=O
biological source
synthetic
assay
≥45% (Adenosine-3′-monophosphate, HPLC)
≥97% (Total Adenosine-3′-monophosphate; Adenosine-2′-monophosphate, HPLC)
10-55% ( Adenosine-2′-monophosphate, HPLC)
form
powder
solubility
1 M NH4OH: 50 mg/mL, clear, colorless
storage temp.
−20°C
Quality Level
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相关类别
Application
腺苷2′(3′)-单磷酸盐混合异构体被用作分离和分离的标准物定量嘌呤(腺嘌呤和鸟嘌呤)和腺嘌呤核糖核苷单磷酸盐（2’-AMP 和 3’-AMP）通过等温高性能液体色谱法 (HPLC)。它也被用来筛选多个糖结合 ATPase A (MsbA) 转运蛋白。
General description
3′-单磷酸腺苷（3′-AMP）和2′-单磷酸腺苷（2′-AMP）是由金属依赖性磷酸二酯酶家族水解2′,3′-cAMP产生的代谢产物。2′-AMP和3′-AMP通过A2B受体抑制肾小球前血管平滑肌细胞和肾小球系膜细胞的增殖。
Other Notes
不要与腺苷 2′:3′-环一磷酸混淆
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Andrea A Putnam et al.
Journal of molecular biology, 425(20), 3839-3845 (2013-05-25)
In eukaryotes, cellular levels of adenosine monophosphate (AMP) signal the metabolic state of the cell. AMP concentrations increase significantly upon metabolic stress, such as glucose deprivation in yeast. Here, we show that several DEAD-box RNA helicases are sensitive to AMP
Li Sheng et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 43(9), 912-916 (2008-12-04)
This paper is aimed to study the metabolic kinetics of nicousamide in rat liver microsomes and cytosol and to identify the major metabolite and drug metabolizing enzymes involved in the metabolism of nicousamide in rat and human liver microsomes by
Sergio Leonardi et al.
Heart (British Cardiac Society), 99(17), 1282-1287 (2013-02-26)
To reassess the efficacy of cangrelor efficacy using the universal definition of myocardial infarction (MI). We adopted a novel approach to systematically implement the universal definition of MI. Two physicians blinded to treatment allocation reviewed plots of CK-MB and troponin
K R Wolthers et al.
Biochemistry, 40(15), 4722-4737 (2001-04-11)
Binding of Ca(2+)-activated calmodulin (Ca(2+)-CaM) to neuronal nitric-oxide synthase (nNOS) increases the rate of 2,6-dichloroindolphenol (DCIP) reduction 2-3-fold and that of cytochrome c(3+) 10-20-fold. Parallel initial velocity patterns indicated that both substrates were reduced via two-half reactions in a ping-pong
Shuji Noguchi
Protein and peptide letters, 17(12), 1559-1561 (2010-09-23)
Asparagine can be non-enzymatically deamidated and isomerized via succinimide to isoaspartate. This post-translational modification can potentially alter the physical properties or the function of the parent protein. Asn32 of ribonuclease U2A from Ustilago sphaerogena is known to rapidly deamidate and
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