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A3085

5-(N-乙基-N-异丙基)阿米洛利

≥98% (TLC), powder, Na⁺/H⁺ antiport inhibitor

别名:

EIPA

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关于此项目

经验公式（希尔记法）:
C11H18ClN7O
化学文摘社编号:
1154-25-2
分子量:
299.76
UNSPSC Code:
12352200
PubChem Substance ID:
24278223
NACRES:
NA.77
MDL number:
MFCD00151710
Assay:
≥98% (TLC)
Form:
powder
Quality level:
200
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产品名称

5-(N-乙基-N-异丙基)阿米洛利,

biological source

synthetic

Quality Level

200

assay

≥98% (TLC)

form

powder

mp

202-205 °C (lit.)

solubility

methanol: 9.80-10.20 mg/mL, clear, light yellow to yellow

storage temp.

2-8°C

SMILES string

CCN(C(C)C)c1nc(N)c(nc1Cl)C(=O)NC(N)=N

InChI

1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)

InChI key

QDERNBXNXJCIQK-UHFFFAOYSA-N

Gene Information

human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548), SLC9A5(6553)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a2(24783), Slc9a3(24784), Slc9a4(24785)

Application

5-(N-乙基-N-异丙基)阿米洛利已用于：
  • 作为内皮细胞生长培养基补充剂，培养人肺微血管内皮细胞
  • 加入Pluronic F-127贮备液，用于果蝇幼虫活体成像
  • 加入氯化胆碱溶液，作为灌注液用于研究Na+/H+对体内空肠环路灌注的抑制作用

Biochem/physiol Actions

Na+/H+反向转运的选择性阻断剂

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000541715
0000541715
0000486013
0000486013
0000453948

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Zhao Luo et al.
Journal of peptide science : an official publication of the European Peptide Society, 22(11-12), 689-699 (2016-10-16)
Cell-penetrating peptides (CPPs) have been shown to be potential drug carriers for cancer therapy. The inherently low immunogenicity and cytotoxicity of human-derived CPPs make them more suitable for intracellular drug delivery compared to other delivery vehicles. In this work, the
Na+/H+ exchange via the Drosophila vesicular glutamate transporter mediates activity-induced acid efflux from presynaptic terminals
Rossano AJ, et al.
The Journal of Physiology, 595(3), 805-824 (2017)
Rachael L Hardison et al.
mSphere, 3(5) (2018-09-14)
Nutrient limitation restricts bacterial growth in privileged sites such as the middle ear. Transient heme-iron restriction of nontypeable Haemophilus influenzae (NTHI), the major causative agent of chronic and recurrent otitis media (OM), promotes new and diverse phenotypes that can influence
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全球贸易项目编号

货号GTIN
A3085-25MG04061833360286
A3085-100MG04061832569055