A3145
芹菜素
≥97% (TLC), from parsley, powder
别名:
4 & # 8242;,5,7-三羟基黄酮, 5,7-二羟基-2-（4-羟基苯基）-4-苯并吡喃酮
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关于此项目
经验公式（希尔记法）:
C15H10O5
化学文摘社编号:
分子量:
270.24
EC Number:
208-292-3
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
262620
MDL number:
InChI key
KZNIFHPLKGYRTM-UHFFFAOYSA-N
InChI
1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
SMILES string
Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
biological source
parsley
assay
≥97% (TLC)
form
powder
color
yellow
mp
>300 °C (lit.)
solubility
DMSO: 27 mg/mL, 1 M KOH: 50 mg/mL
storage temp.
−20°C
Gene Information
human ... ADORA3(140), CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), ESR1(2099), ESR2(2100), GSK3A(2931)
mouse ... Hexa(15211)
rat ... Adora1(29290), Adora2a(25369), Il4(287287), Tnf(24835)
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Biochem/physiol Actions
一种植物类黄酮，研究发现它通过在G2/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。对肿瘤促进的抑制作用也可能是由于激酶活性的抑制以及由此导致的癌基因表达的抑制。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再附着和增强细胞间缝隙连接通讯。
一种植物类黄酮，研究发现它通过在G2/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
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