A3262
腺苷-3′,5′-环单磷酸 三羟甲基氨基甲烷盐
≥97% (HPLC), synthetic, powder
别名:
cAMP, 环磷腺苷
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关于此项目
经验公式（希尔记法）:
C10H12N5O6P · C4H11NO3
化学文摘社编号:
分子量:
450.34
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.51
MDL number:
产品名称
腺苷-3′,5′-环单磷酸 三羟甲基氨基甲烷盐, ≥97% (HPLC), powder
SMILES string
NC(CO)(CO)CO.Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O
InChI
1S/C10H12N5O6P.C4H11NO3/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7;5-4(1-6,2-7)3-8/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13);6-8H,1-3,5H2/t4-,6-,7-,10-;/m1./s1
InChI key
CLDDYJFNXTUHIN-MCDZGGTQSA-N
biological source
synthetic
assay
≥97% (HPLC)
form
powder
color
white
solubility
H2O: 100 mg/mL
storage temp.
−20°C
Quality Level
相关类别
Application
腺苷3′,5′-环一磷酸三盐已被用作人类子宫内膜间质细胞 (hESC) 培养和诱导神经干细胞(iNSC)的培养基补充剂。它已用于pink flamindo（红色 cAMP 指示剂）的光谱表征。
Biochem/physiol Actions
环化腺苷酸依赖性蛋白激酶 (PKA) 的自然活化剂。cAMP 是一种重要的第二信使，并且在很多系统中与神经递质或激素诱导的受体激活相关。已有显示，cAMP/PKA 信号通路可抑制细胞增殖，诱导分化并导致细胞凋亡。
General description
在存在腺苷酸环化酶的存在下，由ATP合成腺苷3′,5′-环一磷酸(cAMP)。 cAMP主要用作免疫化学检测分析中的标记。胞内cAMP水平控制着免疫和炎症功能。细菌感染可触发胞内cAMP产生。 cAMP水平升高可调节癌细胞中的促分裂原活化蛋白激酶(MAPK) 。cAMP水平改变与白内障和心血管疾病的发病机理有关。 cAMP水平降低会触发糖尿病中胰岛素分泌受损。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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