A3281
N-(6-氨基己基)-5-氯-1-萘磺酰胺 盐酸盐
别名:
W-7
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关于此项目
经验公式（希尔记法）:
C16H21ClN2O2S · HCl
化学文摘社编号:
分子量:
377.33
Beilstein:
6030174
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
表单
powder
质量水平
作用机制
cell membrane | interferes
enzyme | inhibits
储存温度
−20°C
SMILES字符串
Cl[H].NCCCCCCNS(=O)(=O)c1cccc2c(Cl)cccc12
InChI
1S/C16H21ClN2O2S.ClH/c17-15-9-5-8-14-13(15)7-6-10-16(14)22(20,21)19-12-4-2-1-3-11-18;/h5-10,19H,1-4,11-12,18H2;1H
InChI key
OMMOSRLIFSCDBL-UHFFFAOYSA-N
基因信息
human ... CAMK2A(815), CAMK2B(816)
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应用
N-(6-氨基己基)-5-氯-1-萘磺酰胺盐酸盐已用于研究其对被膜小窝染色的作用。
生化/生理作用
N-(6-氨基己基)-5-氯-1-萘磺酰胺盐酸盐(W-7)是一种钙调素拮抗剂，可抑制磷脂敏感性钙依赖蛋白激酶。
特点和优势
该化合物是环核苷酸研究的特色产品。点击此处，发现更多特色环核苷酸产品。如需了解有关生物活性小分子在其他研究领域的更多信息，请访问sigma.com/ discover-bsm。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, also inhibits phospholipid sensitive calcium-dependent protein kinase
Schatzman RC, et al.
Biochimica et biophysica acta. General subjects, 755(1), 144-147 (1983)
M Osawa et al.
FEBS letters, 442(2-3), 173-177 (1999-02-03)
Small-angle X-ray scattering and nuclear magnetic resonance were used to investigate the structural change of calcium-bound calmodulin (Ca2+/CaM) in solution upon binding to its antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7). The radius of gyration was 17.4+/-0.3 A for Ca2+/CaM-W-7 with a molar ratio
L González-Fernández et al.
Reproduction (Cambridge, England), 144(4), 411-422 (2012-07-31)
The mechanisms leading to capacitation in stallion sperm are poorly understood. The objective of our study was to define factors associated with regulation of protein tyrosine phosphorylation in stallion sperm. Stallion sperm were incubated for 4 h in modified Whitten's
S M H Alavi et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 160(2), 166-174 (2011-06-10)
The present study shows the roles of osmolality, calcium (Ca(2+))-potassium (K(+)) antagonist and Ca(2+) in sperm activation and flagellar beating of a sturgeon species, sterlet (Acipenser ruthenus). Sperm motility was activated at hypoosmolality relative to seminal plasma and suppressed at
Yukiomi Tsuji et al.
Circulation, 123(20), 2192-2203 (2011-05-11)
Electrical storm (ES), characterized by recurrent ventricular tachycardia/fibrillation, typically occurs in implantable cardioverter-defibrillator patients and adversely affects prognosis. However, the underlying molecular basis is poorly understood. In the present study, we report a new experimental model featuring repetitive episodes of
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Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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