主要文件

查看所有文档

A3401

Ala-Ala-Phe-7-氨基-4-甲基香豆素

Name: Ala-Ala-Phe-7-氨基-4-甲基香豆素
Brand: SIGMA

protease substrate

别名:

H-Ala-Ala-Phe-AMC

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₂₅H₂₈N₄O₅

化学文摘社编号:

62037-41-6

分子量:

464.51

NACRES:

NA.32

PubChem Substance ID:

24890766

UNSPSC Code:

12352204

MDL number:

MFCD00070149

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

Quality Level

200

assay

≥98% (TLC)

form

powder

solubility

ethanol: 20 mg/mL, clear, colorless to light yellow

storage temp.

2-8°C

SMILES string

CC(N)C(=O)NC(C)C(=O)NC(Cc1ccccc1)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2

InChI

1S/C25H28N4O5/c1-14-11-22(30)34-21-13-18(9-10-19(14)21)28-25(33)20(12-17-7-5-4-6-8-17)29-24(32)16(3)27-23(31)15(2)26/h4-11,13,15-16,20H,12,26H2,1-3H3,(H,27,31)(H,28,33)(H,29,32)

InChI key

FVRLYIFIDKXFHU-UHFFFAOYSA-N

General description

丙氨酸-丙氨酸-苯丙氨酸-7-酰胺基-4-甲基香豆素是蛋白水解活性的荧光底物。是带正电荷的底物分子。

糜蛋白酶和三肽基肽酶 ii 的底物。

Application

丙氨酸-丙氨酸-苯丙氨酸-7-酰胺基-4-甲基香豆素已被用于：

酶促反应混合液的制备
启动三肽基肽酶-1 (TPP1) 酶活性测定中的酶反应
启动溶酶体水解酶活性测定中的测定反应

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Effect of interfacial properties on the activation volume of adsorbed enzymes

Schuabb V, et al.

Colloids and Surfaces. B, Biointerfaces, 140, 497-504 (2016)

Accumulation of polyubiquitylated proteins in response to Ala-Ala-Phe-chloromethylketone is independent of the inhibition of tripeptidyl peptidase II

Villasevil E M, et al.

Biochimica et Biophysica Acta - Molecular Cell Research, 1803(9), 1094-1105 (2010)

Purification, substrate specificity, and classification of tripeptidyl peptidase II.

R M Bålöw et al.

The Journal of biological chemistry, 261(5), 2409-2417 (1986-02-15)

An extralysosomal tripeptide-releasing aminopeptidase was recently discovered in rat liver (Bålöw, R.-M., Ragnarsson, U., and Zetterqvist, O. (1983) J. Biol. Chem. 258, 11622-11628). In the present work this tripeptidyl peptidase is shown to occur in several rat tissues and in

Protracted late infantile ceroid lipofuscinosis due to TPP1 mutations: Clinical, molecular and biochemical characterization in three sibs.

Raffaella Di Giacopo et al.

Journal of the neurological sciences, 356(1-2), 65-71 (2015-07-06)

This work investigated the molecular cause responsible for a late-onset parkinsonism-dystonia phenotype in three Italian siblings, and clinically characterize this condition. Extensive neurophysiological and neuroradiological exams were performed on the three sibs. Most frequent late-onset metabolic diseases were ruled out

Upregulation of tripeptidyl-peptidase 1 by 3-hydroxy-(2,2)-dimethyl butyrate, a brain endogenous ligand of PPARα: Implications for late-infantile Batten disease therapy.

Sudipta Chakrabarti et al.

Neurobiology of disease, 127, 362-373 (2019-04-01)

The late-infantile Batten disease or late-infantile neuronal ceroid lipofuscinosis (LINCL) is an autosomal recessive lysosomal storage disorder caused by mutations in the Cln2 gene leading to deficiency of lysosomal enzyme tripeptidyl peptidase 1 (TPP1). At present, available options for this

查看所有相关文献

商品

Chymotrypsin

Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.

全球贸易项目编号

货号	GTIN
A3401-25MG	04061832904146

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持