A3650
阿米卡星 水合物
aminoglycoside antibiotic
别名:
N 1 - [(S)-4-氨基-2-羟基丁酰基] 卡那霉素 A
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关于此项目
经验公式（希尔记法）:
C22H43N5O13 · xH2O
化学文摘社编号:
分子量:
585.60 (anhydrous basis)
UNSPSC Code:
51281632
NACRES:
NA.85
PubChem Substance ID:
EC Number:
253-538-5
Beilstein/REAXYS Number:
1445422
MDL number:
产品名称
阿米卡星 水合物, aminoglycoside antibiotic
InChI key
DTSOZYYWEZJFSS-XTHCGPPUSA-N
InChI
1S/C22H43N5O13.H2O/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);1H2/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;/m0./s1
SMILES string
O.NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O
biological source
synthetic
form
powder
color
white to almost white
antibiotic activity spectrum
Gram-negative bacteria
mycobacteria
mode of action
protein synthesis | interferes
storage temp.
2-8°C
Quality Level
Application
阿米卡星水合物用于对诸如 结核分枝杆菌 和 嗜艾利希体 等微生物的抗菌敏感性研究。
Biochem/physiol Actions
阿米卡星通过与 30S 核糖体亚基结合，诱导 mRNA 误读，从而抑制细菌蛋白质合成。干扰 tRNA 从 A 位点到 P 位点的移位。
General description
化学结构：氨基糖苷类
Other Notes
保存于密闭容器内，置于干燥通风处。
Packaging
5G
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
G J Alangaden et al.
Antimicrobial agents and chemotherapy, 42(5), 1295-1297 (1998-05-21)
An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 microg/ml). High-level cross-resistance may result from such a mutation since MTB has a
H W Horowitz et al.
Antimicrobial agents and chemotherapy, 45(3), 786-788 (2001-02-22)
Human granulocytic ehrlichiosis is a recently described disease caused by an obligate intracellular gram-negative organism recently named Ehrlichia phagocytophila. To expand our knowledge of the susceptibility of E. phagocytophila, we tested six New York State isolates for susceptibility to 12
P Van der Auwera
The Journal of antimicrobial chemotherapy, 27 Suppl C, 63-71 (1991-05-01)
The pharmacokinetic parameters of amikacin given once daily were compared to those of amikacin given bd at different daily dosages. In adult patients, 'peak' serum concentrations (30 min after 30 min infusion) were linearly proportional to the dose given with
M P Goren et al.
The Pediatric infectious disease journal, 8(5), 278-282 (1989-05-01)
A three-drug antibiotic regimen including vancomycin and amikacin has been recommended as effective treatment in clinical settings in which Gram-positive bacteremias are a serious problem. To determine if vancomycin potentiates the tubular proteinuria associated with amikacin therapy, we studied febrile
Sophia B Georghiou et al.
PloS one, 7(3), e33275-e33275 (2012-04-06)
Rapid molecular diagnostics for detecting multidrug-resistant and extensively drug-resistant tuberculosis (M/XDR-TB) primarily identify mutations in Mycobacterium tuberculosis (Mtb) genes associated with drug resistance. Their accuracy, however, is dependent largely on the strength of the association between a specific mutation and
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