A4021
Nε-乙酰基- L -赖氨酸
≥98% (TLC)
别名:
N6-acetyl-L-lysine
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关于此项目
线性分子式:
CH3CONH(CH2)4CH(NH2)CO2H
化学文摘社编号:
分子量:
188.22
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
211-725-9
MDL number:
产品名称
Nε-乙酰基- L -赖氨酸,
InChI key
DTERQYGMUDWYAZ-ZETCQYMHSA-N
InChI
1S/C8H16N2O3/c1-6(11)10-5-3-2-4-7(9)8(12)13/h7H,2-5,9H2,1H3,(H,10,11)(H,12,13)/t7-/m0/s1
SMILES string
CC(=O)NCCCC[C@H](N)C(O)=O
assay
≥98% (TLC)
form
powder
concentration
50 mg/mL in 80% acetic acid
color
colorless to white
mp
250 °C (dec.) (lit.)
storage temp.
−20°C
Quality Level
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Application
- Nε-乙酰基L-α赖氨酸在酸性条件下提高α-淀粉酶的活性和稳定性与其它渗透物的比较研究。该研究强调了Nε-乙酰基-L-赖氨酸在酸性条件下增强α-淀粉酶的功能稳定性和活性，证明了其作为工业酶应用中有价值的添加剂的潜力（Joghee et al., 2020）。
Biochem/physiol Actions
Nε-乙酰基-L-赖氨酸 (L-AcK) 是一种 R 链 N-乙酰化 α氨基酸与其他赖氨酸类似物一起用于区分和表征各种氨基酰化酶和调节因子 2 (Sir2) 酶/去乙酰化酶。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
A Pähler et al.
Chemical research in toxicology, 11(9), 995-1004 (1998-10-07)
Antibodies directed against chemical specific protein modifications are valuable tools to detect and comparatively quantify protein modifications. Both Nepsilon-(dichloroacetyl)-L-lysine and Nepsilon-(trichloroacety)l-L-lysine have been detected as modified amino acids in liver and kidneys of rats treated with perchloroethene (PER) after proteolysis.
Heinz Neumann et al.
Nature chemical biology, 4(4), 232-234 (2008-02-19)
N(epsilon)-acetylation of lysine (1) is a reversible post-translational modification with a regulatory role that rivals that of phosphorylation in eukaryotes. No general methods exist to synthesize proteins containing N(epsilon)-acetyllysine (2) at defined sites. Here we demonstrate the site-specific incorporation of
T Henle et al.
Zeitschrift fur Lebensmittel-Untersuchung und -Forschung, 198(1), 66-67 (1994-01-01)
After heating N alpha-acetyllysine and glucose for 4 h at 90 degrees C in the dry state and subsequent acid hydrolysis with 7.8 N HCl, preparative fractionation of the dihydrochlorides of furosine and pyridosine was achieved by cation-exchange chromatography. The
J A Cohn et al.
Archives of biochemistry and biophysics, 328(1), 158-164 (1996-04-01)
We have previously shown that incubation of the model protein glucose-6-phosphate dehydrogenase (Glu-6-PDH) from the bacterium Leuconostoc mesenteroides with 4-hydroxy-2-nonenal (HNE), a major product of lipid peroxidation, results in the formation of cross-linked protein. HNE-modified protein is resistant to proteolytic
K Hoffmann et al.
Die Pharmazie, 55(8), 601-606 (2000-09-16)
Inhibitors of histone deacetylase (HD) are of great potential as new drugs due to their ability to influence transcriptional regulation and to induce apoptosis or differentiation in cancer cells. So far only radioactive enzyme activity assays or in-vivo assays with
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