A4475
Anti-Annexin VII antibody, Mouse monoclonal
clone 203-217/6, purified from hybridoma cell culture
别名:
Synexin
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关于此项目
Conjugate:
unconjugated
Clone:
203-217/6, monoclonal
Application:
ARR, ICC, IHC (f), WB
Citations:
5
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
203-217/6, monoclonal
form
buffered aqueous solution
mol wt
antigen 47-51 kDa
species reactivity
mouse, canine, rat, chicken, bovine, human, rabbit
technique(s)
immunocytochemistry: suitable using methanol or 1% paraformaldehyde/0.1% glutaraldehyde, immunohistochemistry (frozen sections): suitable, microarray: suitable, western blot: 0.5-1 μg/mL using whole cell extract of culture mouse connective tissue (A9) cells.
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ANXA7(310)
mouse ... Anxa7(11750)
rat ... Anxa7(155423)
General description
Annexin VII (synexin) is a membrane binding protein that localizes in the nucleus and cytosol. In humans and mice, Annexin VII is encoded by a single gene that has alternatively spliced cassette exons. As a result, two isoforms of molecular mass of 47kDa and 51kDa are expressed. These isoforms differ in their N-terminal region and also have distinct tissue-specific expression patterns.
Anti-Annexin VII antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the 203-217/6 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant mouse Annexin VII. The human annexin VII (ANXA7) is located on chromosome 10q21.
Immunogen
recombinant mouse annexin VII.
Application
Anti-Annexin VII antibody, Mouse monoclonal has been used in:
- western blotting
- immunocytochemistry
- immunohistochemistry
Biochem/physiol Actions
Antibodies reacting specifically with Annexin VII serve as an essential tool for the detection of this molecule in various cells. The human annexin VII (ANXA7) possesses a tumor suppressor role in prostate cancer. Hence it can be used an important biomarker along with syndecan-1 to predict the survival rates in prostate cancer patients.
Mouse monoclonal anti-annexin VII antibody reacts with human, bovine, rabbit, dog, rat, mouse, and chicken Annexin VII.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Annexin A7 suppresses lymph node metastasis of hepatocarcinoma cells in a mouse model
Jin Y, et al.
BMC Cancer, 13(1), 522-522 (2013)
Tissue microarray analysis delineate potential prognostic role of Annexin A7 in prostate cancer progression
Leighton X, et al.
Testing, 13(10), e0205837-e0205837 (2018)
Yanling Jin et al.
BMC cancer, 13, 522-522 (2013-11-06)
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death in China. This study investigated the effects of Annexin A7 (ANXA7) on the inhibition of HCC lymph node metastasis in a mouse model. The stable knockup and knockdown
ShuYan Liu et al.
Cancer letters, 416, 11-23 (2017-12-17)
Annexin A7 (ANXA7) is a suppressor of tumorigenesis and metastasis in prostate cancer. Activated ANXA7 GTPase promotes prostate cancer cell apoptosis. However, the role and underlying mechanism of ANXA7 GTPase in prostate cancer metastasis have not been established. RKIP is
C S Clemen et al.
Journal of muscle research and cell motility, 20(7), 669-679 (2000-02-15)
Annexin VII exists in a 47 kDa and a 51 kDa isoform with the 51 kDa protein being the only isoform present in skeletal muscle. Expression of the 51 kDa isoform during myogenesis and localization was studied in cells after
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