A4487
阿非迪霉素，即用型溶液
Ready Made Solution, from Nigrospora sphaerica
别名:
ICI 69653, NSC-234714
生物来源
Nigrospora sphaerica
质量水平
蒸汽压
0.55 hPa ( 20 °C)
表单
liquid
ready-to-use solution
颜色
clear colorless
溶解性
H2O: miscible (completely)
抗生素抗菌谱
neoplastics
viruses
作用机制
DNA synthesis | interferes
enzyme | inhibits
储存温度
−20°C
SMILES字符串
O[C@]1([C@H]2C[C@@]3([C@@]4([C@H]([C@@]([C@@H](CC4)O)(CO)C)CC[C@H]3C2)C)CC1)CO
InChI
1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
InChI key
NOFOAYPPHIUXJR-APNQCZIXSA-N
一般描述
阿非迪霉素(Aphidicolin)是一种四环二萜抗生素，具有抗病毒和抗有丝分裂作用，可用于各种细胞系的细胞周期同步。
应用
阿非迪霉素,来自球黑孢(Nigrospora sphaerica)，可用于烟草BY-2细胞的细胞周期同步。可阻滞细胞进入S期。
生化/生理作用
阿非迪霉素特异性抑制负责DNA复制的DNA聚合酶α。还可抑制植物和酵母的α样DNA聚合酶，但不抑制RNA和蛋白质的合成。阿非迪霉素特异性竞争DNA聚合酶α的dCTP特异性结合位点。阿非迪霉素具有抗病毒和抗有丝分裂作用。可将细胞周期阻滞在S期。已证明其可诱导HeLa细胞凋亡。
包装
1 ml
外形
阿非迪霉素即用型溶液，以1 mg/ml DMSO溶液的形式提供。
其他说明
保存于密闭容器内，置于干燥通风处。储存类别（TRGS 510）：可燃液体
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
188.6 °F - closed cup
闪点(°C)
87 °C - closed cup
K Marheineke et al.
The Journal of biological chemistry, 276(20), 17092-17100 (2001-03-30)
DNA replication origins are located at random with respect to DNA sequence in Xenopus early embryos and on DNA replicated in Xenopus egg extracts. We have recently shown that origins fire throughout the S phase in Xenopus egg extracts. To
G Pedrali-Noy et al.
Nucleic acids research, 8(2), 377-387 (1980-01-25)
Both the inhibitory effect of aphidicolin on the replicative alpha-polymerase and the reversibility of its action in vivo (Pedrali-Noy & Spadari, 1979, Biochem. Biophys. Res. Commun. 88, 1194-2002) allow the synchronization of cells in culture. Aphidicolin prevents G1 cells from
New views of the biochemistry of eucaryotic DNA replication revealed by aphidicolin, an unusual inhibitor of DNA polymerase alpha.
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Cell, 23(3), 647-648 (1981-03-01)
Hui Wang et al.
Cancer research, 77(8), 2148-2160 (2017-02-18)
Overexpression of the EVI1 oncogene is associated typically with aggressive myeloid leukemia, but is also detectable in breast carcinoma where its contributions are unexplored. Analyzing a tissue microarray of 608 breast carcinoma patient specimens, we documented EVI1 overexpression in both
Varinderpal S Dhillon et al.
Teratogenesis, carcinogenesis, and mutagenesis, Suppl 1, 35-45 (2003-03-05)
Fragile sites are nonrandomly located gaps and/or breaks and their expres-sion can be induced by specific culture conditions. There are many reports in the literature that indicate that these sites can act as factors that predispose to specific chromosome aberrations
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