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A4562

5-(N,N-二甲基)阿米洛利 盐酸盐

cAMP-dependent protein kinase inhibitor, powder

别名:

3-氨基-N-(氨基亚氨基乙基)-5-(二甲氨基)-6-氯吡嗪甲酰胺 盐酸盐, DMA

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关于此项目

经验公式（希尔记法）:
C8H12ClN7O · HCl
化学文摘社编号:
1214-79-5
分子量:
294.14
UNSPSC Code:
12352200
PubChem Substance ID:
24278216
NACRES:
NA.77
MDL number:
MFCD00069207
Form:
powder
Quality level:
200
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产品名称

5-(N,N-二甲基)阿米洛利 盐酸盐,

form

powder

Quality Level

200

storage temp.

2-8°C

SMILES string

Cl.CN(C)c1nc(N)c(nc1Cl)C(=O)\N=C(\N)N

InChI

1S/C8H12ClN7O.ClH/c1-16(2)6-4(9)13-3(5(10)14-6)7(17)15-8(11)12;/h1-2H3,(H2,10,14)(H4,11,12,15,17);1H

InChI key

IIUPTHVVXMBJMQ-UHFFFAOYSA-N

Gene Information

human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a2(24783), Slc9a3(24784)

相关类别

Application

5-（N,N-二甲基）阿米洛利盐酸盐是 Na 2 /H + 反式结构的选择性阻滞剂。研究了 5-（N,N-二甲基）阿米洛利盐酸盐减轻炎性疼痛的效用。

Biochem/physiol Actions

Na + /H + 反式结构的选择性阻滞剂；IC50 = 6.9 μM.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000299621
0000299622
0000299622
0000299621
0000259562

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D F Zhao et al.
Nature communications, 8, 14067-14067 (2017-02-22)
The terrestrial vegetation emits large amounts of volatile organic compounds (VOC) into the atmosphere, which on oxidation produce secondary organic aerosol (SOA). By acting as cloud condensation nuclei (CCN), SOA influences cloud formation and climate. In a warming climate, changes
Peter A Alpert et al.
Scientific reports, 7(1), 12693-12693 (2017-10-06)
Organic interfaces that exist at the sea surface microlayer or as surfactant coatings on cloud droplets are highly concentrated and chemically distinct from the underlying bulk or overlying gas phase. Therefore, they may be potentially unique locations for chemical or
Susmita Roy et al.
Nucleic acids research, 47(6), 3158-3170 (2019-01-04)
Investigations of most riboswitches remain confined to the ligand-binding aptamer domain. However, during the riboswitch mediated transcription regulation process, the aptamer domain and the expression platform compete for a shared strand. If the expression platform dominates, an anti-terminator helix is
Matija Lovrak et al.
Nature communications, 8, 15317-15317 (2017-06-06)
Self-assembly provides access to a variety of molecular materials, yet spatial control over structure formation remains difficult to achieve. Here we show how reaction-diffusion (RD) can be coupled to a molecular self-assembly process to generate macroscopic free-standing objects with control
Karin Engström et al.
Archives of toxicology, 91(5), 2067-2078 (2016-11-14)
Arsenic, a carcinogen with immunotoxic effects, is a common contaminant of drinking water and certain food worldwide. We hypothesized that chronic arsenic exposure alters gene expression, potentially by altering DNA methylation of genes encoding central components of the immune system.
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相关内容

Product Information Sheet - A4562

Product Information Sheet

全球贸易项目编号

货号GTIN
A4562-100MG04061832569086
A4562-25MG04061833374672

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