A4660
6-硫代鸟嘌呤
Hybri-Max™, 50 ×, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma
别名:
2-氨基-6-巯嘌呤, 2-氨基-6巯基嘌呤
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关于此项目
经验公式（希尔记法）:
C5H5N5S
化学文摘社编号:
分子量:
167.19
UNSPSC Code:
12352207
NACRES:
NA.75
PubChem Substance ID:
EC Number:
205-827-2
Beilstein/REAXYS Number:
157765
MDL number:
Assay:
~98%
Biological source:
synthetic (organic)
Form:
lyophilized powder
Solubility:
1 M NaOH: 50 mg/mL, clear to slightly hazy
Storage temp.:
room temp
InChI key
WYWHKKSPHMUBEB-UHFFFAOYSA-N
InChI
1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)
SMILES string
NC1=Nc2nc[nH]c2C(=S)N1
biological source
synthetic (organic)
grade
Hybri-Max™
sterility
γ-irradiated
product line
BioXtra
assay
~98%
form
lyophilized powder
concentration
50 ×
technique(s)
cell culture | hybridoma: suitable
impurities
endotoxin, tested
mp
≥300 °C (lit.)
solubility
1 M NaOH: 50 mg/mL, clear to slightly hazy
storage temp.
room temp
Quality Level
Gene Information
human ... IMPDH1(3614), IMPDH2(3615)
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Application
在杂交瘤形成应用中作为选择剂。
Biochem/physiol Actions
核糖基化并通过与天然嘌呤碱相同的途径磷酸化；作为核苷酸，抑制参与核酸合成的多种细胞过程。作为白血病的有效治疗方法已有悠久的历史。
Preparation Note
10mL 无菌细胞培养基可复原一小瓶本品。储存液足以制备 500mL 培养基。最终工作浓度：30μM 2-氨基-6-巯基嘌呤。
Legal Information
Hybri-Max is a trademark of Sigma-Aldrich Co. LLC
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Donghui Li et al.
Nucleic acids research, 49(5), 2642-2654 (2021-02-17)
The CRISPR/Cas9 system is a technology for genome engineering, which has been applied to indel mutations in genes as well as targeted gene deletion and replacement. Here, we describe paired gRNA deletions along the PIGA locus on the human X
N K H de Boer et al.
Digestion, 73(1), 25-31 (2006-02-24)
Recently, the suggestion to use 6-thioguanine (6-TG) as an alternative thiopurine in patients with inflammatory bowel disease (IBD) has been discarded due to reports about possible (hepato) toxicity. During meetings arranged in Vienna and Prague in 2004, European experts applying
Quentin Gueranger et al.
The Journal of investigative dermatology, 134(5), 1408-1417 (2013-11-29)
Damage to skin DNA by solar UV is largely unavoidable, and an optimal cellular response to it requires the coordinated operation of proteins in numerous pathways. A fully functional DNA repair proteome for removing harmful DNA lesions is a prerequisite
Promising treatment of autoimmune hepatitis with 6-thioguanine after adverse events on azathioprine.
Nanne K H de Boer et al.
European journal of gastroenterology & hepatology, 17(4), 457-461 (2005-03-10)
The use of corticosteroids in autoimmune hepatitis is an established therapy. To avoid the possible serious side effects of corticosteroids, immunosuppression with azathioprine is often warranted. Azathioprine, a purine analogue, is frequently used to taper or replace corticosteroids. However, approximately
Reto Brem et al.
Cancer research, 72(18), 4787-4795 (2012-07-24)
The thiopurines azathioprine and 6-mercaptopurine have been extensively prescribed as immunosuppressant and anticancer agents for several decades. A third member of the thiopurine family, 6-thioguanine (6-TG), has been used less widely. Although known to be partly dependent on DNA mismatch
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