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Merck
CN

A4660

6-硫代鸟嘌呤

Hybri-Max™, 50 ×, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma

别名:

2-氨基-6-巯嘌呤, 2-氨基-6巯基嘌呤

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关于此项目

经验公式（希尔记法）:
C5H5N5S
化学文摘社编号:
154-42-7
分子量:
167.19
UNSPSC Code:
12352207
NACRES:
NA.75
PubChem Substance ID:
24890892
EC Number:
205-827-2
Beilstein/REAXYS Number:
157765
MDL number:
MFCD00233553
Assay:
~98%
Biological source:
synthetic (organic)
Form:
lyophilized powder
Solubility:
1 M NaOH: 50 mg/mL, clear to slightly hazy
Storage temp.:
room temp

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产品名称

6-硫代鸟嘌呤, Hybri-Max™, 50 ×, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma

InChI key

WYWHKKSPHMUBEB-UHFFFAOYSA-N

InChI

1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)

SMILES string

NC1=Nc2nc[nH]c2C(=S)N1

biological source

synthetic (organic)

grade

Hybri-Max™

sterility

γ-irradiated

product line

BioXtra

assay

~98%

form

lyophilized powder

concentration

50 ×

technique(s)

cell culture | hybridoma: suitable

impurities

endotoxin, tested

mp

≥300 °C (lit.)

solubility

1 M NaOH: 50 mg/mL, clear to slightly hazy

storage temp.

room temp

Quality Level

200

Gene Information

human ... IMPDH1(3614), IMPDH2(3615)

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相关类别

Application

在杂交瘤形成应用中作为选择剂。

Biochem/physiol Actions

核糖基化并通过与天然嘌呤碱相同的途径磷酸化；作为核苷酸，抑制参与核酸合成的多种细胞过程。作为白血病的有效治疗方法已有悠久的历史。

Preparation Note

10mL 无菌细胞培养基可复原一小瓶本品。储存液足以制备 500mL 培养基。最终工作浓度：30μM 2-氨基-6-巯基嘌呤。

Legal Information

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000330913
0000339114
0000333273
0000311389
0000299468

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Nucleic acids research, 49(5), 2642-2654 (2021-02-17)
The CRISPR/Cas9 system is a technology for genome engineering, which has been applied to indel mutations in genes as well as targeted gene deletion and replacement. Here, we describe paired gRNA deletions along the PIGA locus on the human X
Quentin Gueranger et al.
The Journal of investigative dermatology, 134(5), 1408-1417 (2013-11-29)
Damage to skin DNA by solar UV is largely unavoidable, and an optimal cellular response to it requires the coordinated operation of proteins in numerous pathways. A fully functional DNA repair proteome for removing harmful DNA lesions is a prerequisite
N K H de Boer et al.
Digestion, 73(1), 25-31 (2006-02-24)
Recently, the suggestion to use 6-thioguanine (6-TG) as an alternative thiopurine in patients with inflammatory bowel disease (IBD) has been discarded due to reports about possible (hepato) toxicity. During meetings arranged in Vienna and Prague in 2004, European experts applying
Mark Drost et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(23), 9403-9408 (2013-05-22)
In many individuals suspected of the common cancer predisposition Lynch syndrome, variants of unclear significance (VUS), rather than an obviously pathogenic mutations, are identified in one of the DNA mismatch repair (MMR) genes. The uncertainty of whether such VUS inactivate
Valentin Ruillier et al.
JCI insight, 5(4) (2020-01-29)
Lesch-Nyhan disease (LND) is a rare monogenic disease caused by deficiency of the salvage pathway enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT). LND is characterized by severe neuropsychiatric symptoms that currently cannot be treated. Predictive in vivo models are lacking for screening and
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Product Information Sheet - A4660

Product Information Sheet

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