A4660
6-硫代鸟嘌呤
Hybri-Max™, 50 ×, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma
别名:
2-氨基-6-巯嘌呤, 2-氨基-6巯基嘌呤
生物来源
synthetic (organic)
质量水平
等级
Hybri-Max™
无菌性
γ-irradiated
产品线
BioXtra
方案
~98%
表单
lyophilized powder
浓度
50 ×
技术
cell culture | hybridoma: suitable
杂质
endotoxin, tested
mp
≥300 °C (lit.)
溶解性
1 M NaOH: 50 mg/mL, clear to slightly hazy
储存温度
room temp
SMILES字符串
NC1=Nc2nc[nH]c2C(=S)N1
InChI
1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)
InChI key
WYWHKKSPHMUBEB-UHFFFAOYSA-N
基因信息
human ... IMPDH1(3614), IMPDH2(3615)
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相关类别
应用
在杂交瘤形成应用中作为选择剂。
生化/生理作用
核糖基化并通过与天然嘌呤碱相同的途径磷酸化；作为核苷酸，抑制参与核酸合成的多种细胞过程。作为白血病的有效治疗方法已有悠久的历史。
制备说明
10mL 无菌细胞培养基可复原一小瓶本品。储存液足以制备 500mL 培养基。最终工作浓度：30μM 2-氨基-6-巯基嘌呤。
法律信息
Hybri-Max is a trademark of Sigma-Aldrich Co. LLC
警示用语：
Danger
危险声明
预防措施声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
N K H de Boer et al.
Digestion, 73(1), 25-31 (2006-02-24)
Recently, the suggestion to use 6-thioguanine (6-TG) as an alternative thiopurine in patients with inflammatory bowel disease (IBD) has been discarded due to reports about possible (hepato) toxicity. During meetings arranged in Vienna and Prague in 2004, European experts applying
Donghui Li et al.
Nucleic acids research, 49(5), 2642-2654 (2021-02-17)
The CRISPR/Cas9 system is a technology for genome engineering, which has been applied to indel mutations in genes as well as targeted gene deletion and replacement. Here, we describe paired gRNA deletions along the PIGA locus on the human X
Promising treatment of autoimmune hepatitis with 6-thioguanine after adverse events on azathioprine.
Nanne K H de Boer et al.
European journal of gastroenterology & hepatology, 17(4), 457-461 (2005-03-10)
The use of corticosteroids in autoimmune hepatitis is an established therapy. To avoid the possible serious side effects of corticosteroids, immunosuppression with azathioprine is often warranted. Azathioprine, a purine analogue, is frequently used to taper or replace corticosteroids. However, approximately
Quentin Gueranger et al.
The Journal of investigative dermatology, 134(5), 1408-1417 (2013-11-29)
Damage to skin DNA by solar UV is largely unavoidable, and an optimal cellular response to it requires the coordinated operation of proteins in numerous pathways. A fully functional DNA repair proteome for removing harmful DNA lesions is a prerequisite
Valentin Ruillier et al.
JCI insight, 5(4) (2020-01-29)
Lesch-Nyhan disease (LND) is a rare monogenic disease caused by deficiency of the salvage pathway enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT). LND is characterized by severe neuropsychiatric symptoms that currently cannot be treated. Predictive in vivo models are lacking for screening and
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