A4721
Monoclonal Anti-ARNO (Cytohesin-2) antibody produced in mouse
~2 mg/mL, clone CYT2-21, purified immunoglobulin, buffered aqueous solution
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
CYT2-21, monoclonal
表单
buffered aqueous solution
分子量
antigen 40 kDa
种属反应性
rat, human
浓度
~2 mg/mL
技术
immunocytochemistry: suitable
indirect ELISA: suitable
microarray: suitable
western blot: 5-10 μg/mL using a whole extract of rat brain
同位素/亚型
IgG1
UniProt登记号
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CYTH2(9266)
rat ... Cyth2(116692)
一般描述
ARNO (Cytohesin-2) is a guanine-nucleotide exchange factor that belongs to Arf family of GTP-associated proteins. ARNO has been shown to modulate the movement of mouse preadipocyte 3T3-L1 cells. Studies have reported that cytohesin-2 is overexpressed in pulmonary cancers and can also serve as biomarker of prognosis in hepatocellular carcinomas.
Monoclonal Anti-ARNO (Cytohesin-2) reacts specifically with ARNO, and does not cross-react with other members of the cytohesin family. The antibody associates with human and rat ARNO.
Monoclonal Anti-ARNO (Cytohesin-2) reacts specifically with ARNO, and does not cross-react with other members of the cytohesin family. The antibody associates with human and rat ARNO.
免疫原
recombinant, human ARNO (ARFnucleotide-binding-site opener).
应用
Mouse monoclonal anti-ARNO (Cytohesin-2) antibody can be used for western blot (5-10μg/mL using a whole extract of rat brain), microarray, indirect ELISA and immunocytochemistry applications.
To determine if ARNO binds to phosphoinositides, a protein-overlay assay was performed using monoclonal mouse anti-ARNO as the primary antibody for ARNO detection on membranes spotted with phosphoinositides and incubated with ARNO.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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法规信息
新产品
Kedong Xu et al.
Oncology reports, 29(6), 2211-2218 (2013-04-03)
Cytohesin-2 is overexpressed in human lung cancer and it activates cytoplasmic ErbB receptors. Inhibition of cytohesin-2 by SecinH3 reduces growth of EGFR-dependent lung cancer xenografts and improves the treatment of primarily EGFR-TKI-resistant lung cancers. Cytohesin-2 promotes HepG2 proliferation through the
Tomohiro Torii et al.
The Journal of biological chemistry, 285(31), 24270-24281 (2010-06-08)
The formation of primitive adipose tissue is the initial process in adipose tissue development followed by the migration of preadipocytes into adipocyte clusters. Comparatively little is known about the molecular mechanism controlling preadipocyte migration. Here, we show that cytohesin-2, the
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