A5043
腺苷脱氨酶 来源于牛脾脏
Type X, buffered aqueous glycerol solution, ≥130 units/mg protein
别名:
腺苷脱氨基酶
生物来源
bovine spleen
质量水平
类型
Type X
表单
buffered aqueous glycerol solution
比活
≥130 units/mg protein
分子量
32.5-33 kDa
痕量阳离子
NH4+: ≤10 μg/mg protein
UniProt登记号
异质活性
alkaline phosphatase ≤0.01%
guanase ≤0.01%
nucleoside phosphorylase ≤0.1%
储存温度
2-8°C
基因信息
cow ... ADA(280712)
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一般描述
分子量：32.5-33 kDa
pI: 4.85
pI: 4.85
应用
来自牛脾脏的腺苷脱氨酶已被用于biostrip的固定化，用于稳定性和催化研究。
腺苷脱氨酶可用于各种分子生物学测定，如甘油释放测定。 腺苷脱氨酶是治疗联合免疫缺陷病的潜在靶标。
生化/生理作用
腺苷脱氨酶是一种嘌呤分解代谢酶，其催化腺苷和2′-脱氧腺苷的脱氨基作用，它们具有几乎相同的特异性。它广泛存在于哺乳动物组织中，腺苷脱氨酶缺乏与严重的联合免疫缺陷病有关。
外形
溶于50%甘油，5 mM磷酸钾，pH 6.0
分析说明
通过缩二脲法测定的蛋白质。
其他说明
一个酶活性单位是指在pH 7.5、25℃条件下，每分钟将1.0 μmole 腺苷脱氨基形成肌苷所需的酶量。
储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
动植物源性产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Adenosine reagent-free detection by co-immobilization of adenosine deaminase and phenol red on an optical biostrip
Bartzoka F, et al.
Biotechnology Journal, 10(1), 136-142 (2015)
Ying Cheng et al.
Diabetes, 59(1), 17-25 (2009-10-17)
White adipose tissue (WAT) and brown adipose tissue (BAT) play distinct roles in adaptation to changes in nutrient availability, with WAT serving as an energy store and BAT regulating thermogenesis. We previously showed that mice maintained on a leucine-deficient diet
Yeon-Mi Lee et al.
Biophysical chemistry, 172, 18-25 (2013-01-22)
Human ADAR1, which has two left-handed Z-DNA binding domains, preferentially binds Z-DNA rather than B-DNA with a high binding affinity. Z-DNA can be induced in long genomic DNA by Z-DNA binding proteins through the formation of two B-Z junctions with
George R Thompson et al.
Chest, 143(3), 776-781 (2012-11-29)
In a patient with positive serum serology for coccidioidomycosis, the differential diagnosis of concurrent pleural effusions can be challenging. We, therefore, sought to clarify the performance characteristics of biochemical, serologic, and nucleic-acid-based testing in an attempt to avoid invasive procedures.
Víctor Casanova et al.
PloS one, 7(12), e51287-e51287 (2012-12-15)
ADA is an enzyme implicated in purine metabolism, and is critical to ensure normal immune function. Its congenital deficit leads to severe combined immunodeficiency (SCID). ADA binding to adenosine receptors on dendritic cell surface enables T-cell costimulation through CD26 crosslinking
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