A5222
D-氨基酸氧化酶 来源于猪肾脏
powder, ≥1.5 units/mg solid
别名:
D-AAO, D-氨基酸：氧气 氧化还原酶（脱氨）
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-563-5
MDL number:
Specific activity:
≥1.5 units/mg solid
Application
D-氨基酸氧化酶（DAO）是治疗慢性疼痛和精神分裂症的潜在靶分子。 D-氨基酸氧化酶可用于将D-氨基酸氧化成其相应的亚氨基酸。
Other Notes
在过氧化氢酶存在下，一单位酶在pH 8.3、25℃条件下每分钟可使1.0 μmM D-丙氨酸氧化脱氨成丙酮酸。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
低风险生物材料
此项目有
Natsuki Matsumoto et al.
Methods in molecular biology (Clifton, N.J.), 1887, 23-31 (2018-12-07)
Fermented foods produced using edible microorganisms have been consumed worldwide since ancient times. Microorganisms produce some healthy functional substances. Recently, many people have been attracted to the notion that D-body amino acids have healthy functional effects. D-body amino acids convert
Jin-Lu Huang et al.
Amino acids, 43(5), 1905-1918 (2012-09-22)
D-Amino acid oxidase (DAAO), a FAD-dependent peroxisomal flavoenzyme that catalyzes oxidation of D-amino acids to hydrogen peroxide, is distributed in the spinal cord almost exclusively expressed within astrocytes. The present study aims to explore potential contributions of spinal DAAO to
Norihiro Shibuya et al.
Nature communications, 4, 1366-1366 (2013-01-24)
In eukaryotes, hydrogen sulphide acts as a signalling molecule and cytoprotectant. Hydrogen sulphide is known to be produced from L-cysteine by cystathionine β-synthase, cystathionine γ-lyase and 3-mercaptopyruvate sulfurtransferase coupled with cysteine aminotransferase. Here we report an additional biosynthetic pathway for
R M Abou El-Magd et al.
Journal of psychopharmacology (Oxford, England), 24(7), 1055-1067 (2009-03-31)
D-Amino acid oxidase (DAO) has been established to be involved in the oxidation of D-serine, an allosteric activator of the N-methyl-D-aspartate-type glutamate receptor in the brain, and to be associated with the onset of schizophrenia. The effect of risperidone, a
Seth C Hopkins et al.
The Journal of pharmacology and experimental therapeutics, 345(3), 502-511 (2013-03-23)
Inhibition of d-amino acid oxidase (DAAO) activity is a potential target for the treatment of chronic pain. Here we characterized the effects of systemic administration of the DAAO inhibitor 4H-furo[3,2-b]pyrrole-5-carboxylic acid (SUN) in rat models of neuropathic and inflammatory pain.
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