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A5512

马兜铃酸I

Name: 马兜铃酸I
Brand: SIGMA

≥90% (HPLC), powder, phospholipase A₂ inhibitor

别名:

TR 1736

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关于此项目

经验公式（希尔记法）:

C₁₇H₁₁NO₇

化学文摘社编号:

313-67-7

分子量:

341.27

NACRES:

NA.77

PubChem Substance ID:

24890982

UNSPSC Code:

41106300

EC Number:

206-238-3

MDL number:

MFCD00004996

Assay:

≥90% (HPLC)

Form:

powder

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产品名称

马兜铃酸I, powder

assay

≥90% (HPLC)

form

powder

color

yellow

mp

269-270 °C

solubility

DMSO: soluble, ethanol: soluble

storage temp.

2-8°C

SMILES string

COc1cccc2c1cc([N+]([O-])=O)c3c(cc4OCOc4c23)C(O)=O

InChI

1S/C17H11NO7/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13/h2-6H,7H2,1H3,(H,19,20)

InChI key

BBFQZRXNYIEMAW-UHFFFAOYSA-N

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General description

马兜铃酸是一种天然植物代谢物，存在于马兜铃属、Bragantia属或细辛属植物中。它包括硝基菲羧酸（如马兜铃酸I和II）的混合物。

Application

马兜铃酸I 已用于：

作为标准品，通过高效液相色谱法分析云杉马兜铃粗提物
研究对组蛋白去乙酰化酶3（HDAC3）畸变和肾纤维化的影响
诱导急性马兜铃酸肾病，研究对小鼠miRNA和mRNA表达的影响

Biochem/physiol Actions

有效的磷脂酶A₂ 抑制剂，包括钙离子载体诱导的嗜中性粒细胞磷脂酶A₂ 活性。实验动物模型的肾肿瘤引发剂。

马兜铃酸是蛇毒中磷脂酶A2（PLA2）、透明质酸酶和乙酰胆碱酯酶血浆蛋白酶的有效抑制剂。马兜铃酸被认为是一种草药，对产科、蛇咬伤、痛风和风湿病有治疗作用。它具有抗炎和抗疟疾的特性。此外，它还被认为是一种基因毒性诱变原，可引起马兜铃酸肾病（AAN），特征为间质纤维化和尿路上皮癌。

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H340,H350

pcodes

P202 - P264 - P280 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1A - Muta. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

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Autophagy induction promotes aristolochic acid-I-induced renal injury in vivo and in vitro.

Ching-Chin Yang et al.

Toxicology, 312, 63-73 (2013-08-14)

Studies have found that ingestion of aristolochic acid (AA) causes nephropathy first by inducing renal tubular cell apoptosis acutely. It is currently unknown whether crosstalk between autophagy and apoptosis orchestrates the fate of tubular cells in acute AA nephropathy. We

Integrative microRNA and mRNA expression profiling in acute aristolochic acid nephropathy in mice.

Ziqiang Zhu et al.

Molecular medicine reports, 22(4), 3367-3377 (2020-09-19)

In acute aristolochic acid nephropathy (AAN), aristolochic acid (AA) induces renal injury and tubulointerstitial fibrosis. However, the roles of microRNAs (miRNAs/miRs) and mRNAs involved in AAN are not clearly understood. The aim of the present study was to examine AA‑induced

Anti‑fibrotic effect of Sedum sarmentosum Bunge extract in kidneys via the hedgehog signaling pathway.

Yongheng Bai et al.

Molecular medicine reports, 16(1), 737-745 (2017-06-01)

Sedum sarmentosum Bunge (SSBE) is a perennial plant widely distributed in Asian countries, and its extract is traditionally used for the treatment of certain inflammatory diseases. Our previous studies demonstrated that SSBE has marked renal anti‑fibrotic effects. However, the underlying molecular

A new reversed-phase/strong anion-exchange mixed-mode stationary phase based on polar-copolymerized approach and its application in the enrichment of aristolochic acids.

Jie Wei et al.

Journal of chromatography. A, 1246, 129-136 (2012-04-10)

A novel silica-based reversed-phase/strong anion-exchange mixed-mode stationary phase named C18SAX was synthesized based on the polar-copolymerized approach. C18SAX stationary phase showed excellent compatibility with 100% aqueous mobile phase and comparable performance with commercial SunFire™ C18 column in terms of column

Isolation and structural characterization of bioactive compound from Aristolochia sprucei aqueous extract with anti-myotoxic activity.

Isela I González Rodríguez et al.

Toxicon: X, 7, 100049-100049 (2020-07-03)

A bioactive compound isolated from the stem extract of Aristolochia sprucei through High Performance Liquid Chromatography (HPLC) was identified via Nuclear Magnetic Resonance (NMR) as the aristolochic acid (AA). This compound showed an inhibitory effect over the myotoxic activity of

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全球贸易项目编号

货号	GTIN
A5512-100MG	04061833258194
A5512-25MG	04061833375969

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