A5585
5-（N-甲基-N-异丁基）阿米洛利
≥98% (TLC), powder
别名:
MIA
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关于此项目
经验公式（希尔记法）:
C11H18ClN7O
化学文摘社编号:
分子量:
299.76
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (TLC)
表单
powder
mp
200-201 °C
溶解性
methanol: 9.80-10.20 mg/mL, clear, pale yellow to yellow
储存温度
2-8°C
SMILES字符串
CC(C)CN(C)c1nc(N)c(nc1Cl)C(=O)NC(N)=N
InChI
1S/C11H18ClN7O/c1-5(2)4-19(3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
InChI key
RVIUMPLAOXSSGN-UHFFFAOYSA-N
基因信息
human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768)
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相关类别
应用
5-（N-甲基-N-异丁基）阿米洛利是Na+/H+反向转运的有效阻滞剂。 5-（N-甲基-N-异丁基）阿米洛利已用于研究对酸中毒的早期细胞反应。
生化/生理作用
Na+/H+反向转运的有效阻滞剂。 可能的抗肿瘤药物。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
X H Xiao et al.
Circulation research, 85(8), 723-730 (1999-10-16)
The role of the Na(+)/H(+) exchanger in ischemia, reperfusion, and preconditioning was investigated in isolated perfused rat hearts. Contractile function, [Na(+)](i), and pH(i) were measured; ischemic damage was assessed by the recovery of developed pressure (DP) on reperfusion. After 30
R P Maidorn et al.
British journal of cancer, 67(2), 297-303 (1993-02-01)
The extracellular pH (pHe) in solid tumours is frequently lower than the pHe in normal tissues. Cells within an acidic environment depend on mechanisms which regulate intracellular pH (pHi) for their survival, including the Na+/H+ antiport which exports protons in
D R Sagar et al.
Osteoarthritis and cartilage, 23(6), 906-913 (2015-01-28)
Although analgesic approaches targeting nerve growth factor (NGF) for the treatment of osteoarthritis (OA) pain remain of clinical interest, neurophysiological mechanisms by which NGF contribute to OA pain remain unclear. We investigated the impact of local elevation of knee joint
Mohamed M Helmy et al.
Brain : a journal of neurology, 135(Pt 11), 3311-3319 (2012-11-06)
Birth asphyxia is often associated with a high seizure burden that is predictive of poor neurodevelopmental outcome. The mechanisms underlying birth asphyxia seizures are unknown. Using an animal model of birth asphyxia based on 6-day-old rat pups, we have recently
R J MacLeod et al.
The Journal of membrane biology, 172(1), 47-58 (1999-11-07)
We studied the relationship between changes in intracellular pH (pH(i)), intracellular Ca(2+)([Ca(2+)](i)) and charybdotoxin sensitive (CTX) maxi-K(+) channels occurring after modest 'physiological' swelling in guinea pig jejunal villus enterocytes. Villus cell volume was assessed by electronic cell sizing, and pH(i)
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