A5602
AMD3100 八盐酸盐 水合物
≥97% (NMR), solid, CXCR4 antagonist
别名:
1,1′-[1,4-亚苯基双（亚甲基）]双-1,4,8,11-四氮杂 八盐酸盐, JM3100, SID791, 普乐沙福
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关于此项目
经验公式（希尔记法）:
C28H54N8 · 8HCl · xH2O
化学文摘社编号:
分子量:
794.47 (anhydrous basis)
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
产品名称
AMD3100 八盐酸盐 水合物, ≥97% (NMR), solid
Quality Level
assay
≥97% (NMR)
form
solid
storage condition
desiccated
solubility
H2O: ≥10 mg/mL, clear
originator
Sanofi Aventis
storage temp.
−20°C
SMILES string
Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].[H]O[H].C1CNCCNCCCN(CCNC1)Cc2ccc(CN3CCCNCCNCCCNCC3)cc2
InChI
1S/C28H54N8.8ClH.H2O/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36;;;;;;;;;/h5-8,29-34H,1-4,9-26H2;8*1H;1H2
InChI key
GKFHDCZYJHUPEN-UHFFFAOYSA-N
Application
AMD3100是一种高度特异性的趋化因子受体CXCR4的拮抗剂。 AMD3100已被用于一项研究，以确定其对口腔鳞状细胞癌中CXCR4的阻断和对淋巴结转移的抑制。
Biochem/physiol Actions
AMD3100是一种高度特异性的趋化因子受体CXCR4的拮抗剂。
Features and Benefits
该化合物是由 Sanofi Aventis开发。浏览其他医药开发的化合物和已批准的药物/候选药物清单，请点击这里。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Journal of immunology (Baltimore, Md. : 1950), 192(7), 3180-3189 (2014-03-04)
The majority of allogeneic stem cell transplants are currently undertaken using G-CSF mobilized peripheral blood stem cells. G-CSF has diverse biological effects on a broad range of cells and IL-10 is a key regulator of many of these effects. Using
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Journal of immunology (Baltimore, Md. : 1950), 191(12), 6241-6249 (2013-11-19)
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Sapna Devi et al.
The Journal of experimental medicine, 210(11), 2321-2336 (2013-10-02)
Blood neutrophil homeostasis is essential for successful host defense against invading pathogens. Circulating neutrophil counts are positively regulated by CXCR2 signaling and negatively regulated by the CXCR4-CXCL12 axis. In particular, G-CSF, a known CXCR2 signaler, and plerixafor, a CXCR4 antagonist
Christine Feig et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(50), 20212-20217 (2013-11-28)
An autochthonous model of pancreatic ductal adenocarcinoma (PDA) permitted the analysis of why immunotherapy is ineffective in this human disease. Despite finding that PDA-bearing mice had cancer cell-specific CD8(+) T cells, the mice, like human patients with PDA, did not
Patricia Balsas et al.
Blood, 130(4), 501-513 (2017-05-24)
SOX11 overexpression in mantle cell lymphoma (MCL) has been associated with more aggressive behavior and worse outcome. However, SOX11 oncogenic pathways driving MCL tumor progression are poorly understood. Here, we demonstrate that SOX11 binds to regulatory regions of 2 important
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Product Information Sheet
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A5602-5MG | 04061833376096 |
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