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文件

安全信息

A5686

Sigma-Aldrich

Arg-Gly-Glu-Ser acetate salt

≥95% (HPLC)

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经验公式（希尔记法）:
C16H29N7O8
CAS号:
159002-32-1
分子量:
447.44
MDL编号:
MFCD00133106
PubChem化学物质编号:
329770831
NACRES:
NA.32

生物来源

synthetic (organic)

质量水平

200

检测方案

≥95% (HPLC)

形式

powder

储存温度

−20°C

SMILES string

CC(O)=O.N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O

InChI

1S/C16H29N7O8.C2H4O2/c17-8(2-1-5-20-16(18)19)13(28)21-6-11(25)22-9(3-4-12(26)27)14(29)23-10(7-24)15(30)31;1-2(3)4/h8-10,24H,1-7,17H2,(H,21,28)(H,22,25)(H,23,29)(H,26,27)(H,30,31)(H4,18,19,20);1H3,(H,3,4)/t8-,9-,10-;/m0./s1

InChI key

SALKOFBHHIHLSW-PUBMXKGKSA-N

Gene Information

human ... FN1(2335)
mouse ... FN1(14268)
rat ... FN1(25661)

Amino Acid Sequence

Arg-Gly-Glu-Ser

应用

Arg-Gly-Glu-Ser acetate salt has been used:
  • as an integrin blocking peptide to study its effects on ciliary neurotrophic factor (CNTF) regulation in astroglioma cells
  • as a control peptide to study its effects on the binding of patient IgG to integrin αvβ6
  • as an integrin inhibitor peptide to study its effects on cell adhesion in Capsaspora owczarzaki cells

生化/生理作用

Arg-Gly-Glu-Ser peptide acts as an integrin-blocking peptide.
Inhibitor of platelet aggregation

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品

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Seong Su Kang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(27), 9277-9287 (2012-07-06)
Ciliary neurotrophic factor (CNTF) is a potent neural cytokine with very low expression in the CNS, predominantly by astrocytes. CNTF increases rapidly and greatly following traumatic or ischemic injury. Understanding the underlying mechanisms would help to design pharmacological treatments to
Helena Parra-Acero et al.
Current biology : CB, 30(21), 4270-4275 (2020-08-29)
In animals, cell-matrix adhesions are essential for cell migration, tissue organization, and differentiation, which have central roles in embryonic development [1-6]. Integrins are the major cell surface adhesion receptors mediating cell-matrix adhesion in animals. They are heterodimeric transmembrane proteins that
Gartner, T.K., et al.
Blood, 66, 305a-305a (1985)
Changsuk Moon et al.
Respiratory research, 10, 18-18 (2009-03-11)
Synthetic peptides containing the RGD sequence inhibit integrin-related functions in different cell systems. Here, we investigated the effects of synthetic Arg-Gly-Asp-Ser (RGDS) peptide on key inflammatory responses to intratracheal (i.t.) lipopolysaccharide (LPS) treatment and on the integrin signaled mitogen-activated protein
Anti-Integrin I?vI?6 Antibody as a Diagnostic Marker for Pediatric Patients With Ulcerative Colitis.
Muramoto, et al.
Gastroenterology, 163, 1094-1097 (2022)
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