A5686
Arg-Gly-Glu-Ser acetate salt
≥95% (HPLC)
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关于此项目
经验公式（希尔记法）:
C16H29N7O8
化学文摘社编号:
分子量:
447.44
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Form:
powder
Assay:
≥95% (HPLC)
Biological source:
synthetic (organic)
biological source
synthetic (organic)
Quality Level
assay
≥95% (HPLC)
form
powder
storage temp.
−20°C
SMILES string
CC(O)=O.N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O
InChI
1S/C16H29N7O8.C2H4O2/c17-8(2-1-5-20-16(18)19)13(28)21-6-11(25)22-9(3-4-12(26)27)14(29)23-10(7-24)15(30)31;1-2(3)4/h8-10,24H,1-7,17H2,(H,21,28)(H,22,25)(H,23,29)(H,26,27)(H,30,31)(H4,18,19,20);1H3,(H,3,4)/t8-,9-,10-;/m0./s1
InChI key
SALKOFBHHIHLSW-PUBMXKGKSA-N
Gene Information
human ... FN1(2335)
mouse ... FN1(14268)
rat ... FN1(25661)
Application
Arg-Gly-Glu-Ser acetate salt has been used:
- as an integrin blocking peptide to study its effects on ciliary neurotrophic factor (CNTF) regulation in astroglioma cells
- as a control peptide to study its effects on the binding of patient IgG to integrin αvβ6
- as an integrin inhibitor peptide to study its effects on cell adhesion in Capsaspora owczarzaki cells
Biochem/physiol Actions
Arg-Gly-Glu-Ser peptide acts as an integrin-blocking peptide.
Inhibitor of platelet aggregation
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
Helena Parra-Acero et al.
Current biology : CB, 30(21), 4270-4275 (2020-08-29)
In animals, cell-matrix adhesions are essential for cell migration, tissue organization, and differentiation, which have central roles in embryonic development [1-6]. Integrins are the major cell surface adhesion receptors mediating cell-matrix adhesion in animals. They are heterodimeric transmembrane proteins that
Seong Su Kang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(27), 9277-9287 (2012-07-06)
Ciliary neurotrophic factor (CNTF) is a potent neural cytokine with very low expression in the CNS, predominantly by astrocytes. CNTF increases rapidly and greatly following traumatic or ischemic injury. Understanding the underlying mechanisms would help to design pharmacological treatments to
Changsuk Moon et al.
Respiratory research, 10, 18-18 (2009-03-11)
Synthetic peptides containing the RGD sequence inhibit integrin-related functions in different cell systems. Here, we investigated the effects of synthetic Arg-Gly-Asp-Ser (RGDS) peptide on key inflammatory responses to intratracheal (i.t.) lipopolysaccharide (LPS) treatment and on the integrin signaled mitogen-activated protein
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A5686-2MG | 04061833258392 |
| A5686-10MG | 04061833258385 |
| A5686-5MG | 04061833258408 |