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Merck
CN

A5730

Abz-SDK(Dnp)P-OH 三氟乙酸盐

≥91% (HPLC), lyophilized powder

别名:

o-aminobenzoic acid-Ser-Asp-Lys(DNP)Pro-OH 三氟乙酸盐

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关于此项目

经验公式（希尔记法）:
C31H38N8O13 · xC2HF3O2
化学文摘社编号:
1217465-57-0
分子量:
730.68 (free base basis)
NACRES:
NA.77
PubChem Substance ID:
24891013
UNSPSC Code:
12352200
MDL number:
MFCD09753055

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InChI key

IFSUGURCQHMSJS-JPIABUGISA-N

SMILES string

OC(=O)C(F)(F)F.Nc1ccccc1C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCNc2ccc(cc2[N+]([O-])=O)[N+]([O-])=O)C(=O)N3CCC[C@H]3C(O)=O

InChI

1S/C31H38N8O13.C2HF3O2/c32-19-7-2-1-6-18(19)27(43)36-23(16-40)29(45)35-22(15-26(41)42)28(44)34-21(30(46)37-13-5-9-24(37)31(47)48)8-3-4-12-33-20-11-10-17(38(49)50)14-25(20)39(51)52;3-2(4,5)1(6)7/h1-2,6-7,10-11,14,21-24,33,40H,3-5,8-9,12-13,15-16,32H2,(H,34,44)(H,35,45)(H,36,43)(H,41,42)(H,47,48);(H,6,7)/t21-,22-,23-,24-;/m0./s1

assay

≥91% (HPLC)

form

lyophilized powder

solubility

H2O: freely soluble

storage temp.

2-8°C

Quality Level

100

Application

Abz-SDK(Dnp)P-OH trifluoroacetate is an Angiotensin Converting Enzyme (ACE) fluorescent peptide substrate that specifically binds to the N domain of ACE. Abz-SDK(Dnp)P-OH has been used to study tipifarnib-induced apoptosis in acute myeloid leukemia and multiple myeloma cells.

Biochem/physiol Actions

Abz-SDK(Dnp)P-OH is an Angiotensin Converting Enzyme (ACE) fluorescent peptide substrate specific for the N domain for real time fluorescent assay (ACE, Peptidyl Dipeptidase, Kininase II, E.C. 3.4.15.1).

Features and Benefits

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

动植物源性产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
037K4704V
037K4704V
037K4704

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Niranjan Yanamandra et al.
The Journal of pharmacology and experimental therapeutics, 337(3), 636-643 (2011-03-08)
A major contributing factor to the high mortality rate associated with acute myeloid leukemia and multiple myeloma is the development of resistance to chemotherapy. We have shown that the combination of tipifarnib, a nonpeptidomimetic farnesyltransferase inhibitor (FTI), with bortezomib, a
Christopher D Cerruti et al.
Analytical and bioanalytical chemistry, 401(1), 75-87 (2011-03-08)
Mass spectrometry imaging of lipids using MALDI-TOF/TOF mass spectrometers is of growing interest for chemical mapping of organic compounds at the surface of tissue sections. Many efforts have been devoted to the best matrix choice and deposition technique. Nevertheless, the
Jun Lu et al.
Bioorganic & medicinal chemistry, 18(21), 7628-7638 (2010-10-05)
An efficient synthesis has provided access to a novel α-tocopherol analogue (2), as well as its trifluoroacetate salt and acetate ester. An annulation reaction was used to establish the pyridinol core structure and a Stille coupling reaction was employed for

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