A5879
2-异硫脲 二氢溴酸
≥98% (TLC), NOS inhibitor, powder
别名:
2-(2-Aminoethyl)-2-thiopseudourea dihydrobromide, AET, S-(2-Aminoethyl)isothiouronium bromide hydrobromide
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关于此项目
线性分子式:
NH2CH2CH2SC(=NH)NH2 · 2HBr
化学文摘社编号:
分子量:
281.01
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-257-0
MDL number:
Beilstein/REAXYS Number:
3911163
产品名称
2-异硫脲 二氢溴酸,
InChI key
XDVMCVGTDUKDHL-UHFFFAOYSA-N
InChI
1S/C3H9N3S.2BrH/c4-1-2-7-3(5)6;;/h1-2,4H2,(H3,5,6);2*1H
SMILES string
Br[H].Br[H].NCCSC(N)=N
assay
≥98% (TLC)
form
powder
mp
190-196 °C (lit.)
solubility
water: 50 mg/mL, clear to very slightly hazy, colorless to yellow
Quality Level
Gene Information
human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
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Application
2-(2-Aminoethyl)isothiourea dihydrobromide inhibits nitric oxide synthase (NOS).
Biochem/physiol Actions
Inhibits constitutive and inducible NOS.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
O A Strand et al.
Scandinavian journal of clinical and laboratory investigation, 57(2), 105-109 (1997-04-01)
The effect of inhibiting nitric oxide (NO) synthesis during sepsis was studied in a caecal perforation model on Wistar rats. This model induces severe abdominal sepsis with a 48-h mortality > 90% in untreated animals. The survival time in hours
J L Fuentes et al.
Mutation research, 422(2), 339-345 (1998-12-05)
The effect of sodium diethyldithiocarbamate (DDC) and S-2-aminoethyl-isothiouronicadenosin-5-triphosphate (adeturon) in the induction of Escherichia coli SOS response promoted by gamma-irradiation was studied by measuring the induction of sulA gene and the induction of lambda prophage. Furthermore, as a way of
Y Gundersen et al.
The European journal of surgery = Acta chirurgica, 165(12), 1167-1174 (2000-01-15)
To examine the effects of the inducible nitric oxide synthase inhibitor aminoethyl-isothiourea (AE-ITU) on haemodynamic measurements, and correlate these with hepatic morphology and function in a porcine model of endotoxaemia. Experimental study. 15 juvenile pigs. Flow probes were placed around
A Southey et al.
International journal of immunopharmacology, 19(11-12), 669-676 (1998-07-21)
Overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) may contribute to the pathophysiology of ulcerative colitis. A 2,4,6-trinitrobenzenesulfonic acid sodium salt (TNBS) colitis model was established to examine the effect of selective iNOS inhibition, by S-(2-aminoethyl) isothiouronium
C O Corso et al.
Journal of hepatology, 28(1), 61-69 (1998-04-16)
The question whether nitric oxide protects or impairs organ perfusion during early endotoxemia has not been completely answered. To evaluate the regulative function of nitric oxide on organ microvascular perfusion and leukocyte accumulation during endotoxemia, we studied the influence of
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