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Merck
CN

A5922

氨磷汀 三水合物

≥97% (TLC), powder

别名:

2-(3-氨丙基)氨基乙基硫代磷酸酯, WR2721

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关于此项目

经验公式(希尔记法):
C5H15N2O3PS · 3 H2O
化学文摘社编号:
分子量:
268.27
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥97% (TLC)
Form:
powder
Quality level:
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Quality Level

assay

≥97% (TLC)

form

powder

storage temp.

2-8°C

SMILES string

OP(SCCNCCCN)(O)=O.O.O.O

InChI

1S/C5H15N2O3PS.3H2O/c6-2-1-3-7-4-5-12-11(8,9)10;;;/h7H,1-6H2,(H2,8,9,10);3*1H2

InChI key

TXQPXJKRNHJWAX-UHFFFAOYSA-N

Application

氨磷汀可以使用生长抑素类似物减轻辐射损伤并减少吸收的肾脏辐射剂量,从而在PRRT期间提供肾脏保护。氨磷汀可补救辐射对鼠下颌骨矿化能力的退化作用。

Biochem/physiol Actions

辐射防护剂。选择性地保护正常组织免受抗肿瘤放射疗法的破坏作用。选择性归因于正常组织的优先摄取以及随后对2-(3-氨基丙基)氨基乙硫醇的代谢活化。


Hazard Classifications

Acute Tox. 4 Oral

pictograms

Exclamation mark

signalword

Warning

hcodes

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Jorrit W van As et al.
The Cochrane database of systematic reviews, 5(5), CD009219-CD009219 (2012-05-18)
Platinum-based therapy, including cisplatin, carboplatin and/or oxaliplatin, is used to treat a variety of paediatric malignancies. Unfortunately, one of the most important adverse effects is the occurrence of hearing loss or ototoxicity. In an effort to prevent this ototoxicity, different
V Vendramini et al.
Human reproduction (Oxford, England), 27(8), 2457-2466 (2012-05-18)
In a previous study, we found that amifostine provides some protection to the seminiferous epithelium of prepubertal doxorubicin-treated male rats but does not improve their fertility status as adults. Based on these results, a long-term study was undertaken to evaluate
Marleen Melis et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 53(5), 749-753 (2012-04-13)
Megalin-mediated renal retention of radiolabeled somatostatin analogs may lead to nephrotoxicity during peptide receptor radionuclide therapy (PRRT). The cytoprotective agent amifostine protected rats from long-term nephrotoxicity after PRRT with (177)Lu-DOTA,Tyr(3)-octreotate. This study describes the direct effect of amifostine on kidney



全球贸易项目编号

货号GTIN
A5922-100MG04061833376607