A5963
抗-c-Myc
clone 9E10, purified from hybridoma cell culture
别名:
Anti-c-Myc, Monoclonal Anti-c-Myc−Alkaline Phosphatase antibody produced in mouse
产品名称
抗-c-Myc, clone 9E10, purified from hybridoma cell culture
biological source
mouse
conjugate
alkaline phosphatase conjugate
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
9E10, monoclonal
form
buffered aqueous glycerol solution
species reactivity
human
technique(s)
ELISA: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: 1:100 using a myc-tagged fusion protein.
isotype
IgG1
UniProt accession no.
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... MYC(4609)
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Immunogen
人p62c-Myc蛋白的合成肽。
Application
Anti-c-Myc-Alkaline Phosphatase antibody has been used in
- enzyme linked immunosorbent assay (ELISA)
- immunohistochemical labeling
- immunostaining
- western blotting
Monoclonal Anti-c-Myc-Alkaline Phosphatase antibody can be used for western blot assays at 1:100, using myc-tagged fusion proteins. The antibody can also be used for immunohistochemical applications.
Biochem/physiol Actions
The c-myc oncogene product(p62c-myc) exerts normal and oncogenic cellular functions. Elevated level of c-myc protein in malignant tissues when compared with normal tissue, but with the unexpected finding of a cytoplasmic accumulation of the protein in these tumors.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Monoclonal Anti-c-myc (mouse IgG1 isotype) is derived from the 9E10 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized BALB/c mouse. The c-myc gene encodes for a protein of 62kDa called p62c-myc is associated mainly with cell nuclei.
Physical form
Solution in 0.05 M Tris buffer, containing 1% bovine serum albumin, 1 mM MgCl2, 50% glycerol, and 15 mM sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.
Evan G I, et al.
Molecular and Cellular Biology, 5(12), 3610-3616 (1985)
Novel ganglioside antigen identified by B cells in human medullary breast carcinomas: the proof of principle concerning the tumor-infiltrating B lymphocytes
Kotlan B, et al.
Journal of Immunology, 175(4), 2278-2285 (2005)
Structural and functional insights into the lipopolysaccharide ABC transporter LptB 2 FG
Dong H, et al.
Nature Communications, 8(1), 222-222 (2017)
Ubiquitin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z variant alpha-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy
Feng,L, et al.
Autophagy, 13(4), 686-702 (2017)
Zhenfang Du et al.
Nature communications, 12(1), 1382-1382 (2021-03-04)
Mechanistic understanding of oncogenic variants facilitates the development and optimization of treatment strategies. We recently identified in-frame, tandem duplication of EGFR exons 18 - 25, which causes EGFR Kinase Domain Duplication (EGFR-KDD). Here, we characterize the prevalence of ERBB family
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