A5971
抗水通道蛋白4 兔抗
lyophilized powder, affinity isolated antibody
别名:
抗AQP4, 抗WCH4, 抗汞不敏感性水通道蛋白
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
FACS, ICC, IHC, WB
Citations:
70
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human, mouse, rat
technique(s)
flow cytometry: suitable (indirect), immunocytochemistry: suitable, immunohistochemistry: suitable, western blot: suitable
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... AQP4(361)
mouse ... Aqp4(11829)
rat ... Aqp4(25293)
General description
AQP4是一种调节中枢神经系统水流量的渗透压感受器。它在星形胶质细胞中含量丰富，而在肺、肠、眼和肾组织中含量较少。兔抗水通道蛋白4抗体可识别人、小鼠和大鼠中的水通道蛋白4。
Immunogen
对应于与GST融合的大鼠AQP4的残基249-323的重组融合蛋白。
Application
兔抗水通道蛋白4抗体可用于免疫组化。该抗体还可用于免疫细胞化学、蛋白质印迹和流式细胞术应用。
Biochem/physiol Actions
使用2μl/mll的兔抗AQP4作为一抗，对使用GFP-AQP4转染的HEK-293细胞进行免疫沉淀和蛋白质印迹分析。
Physical form
从含有1%牛血清白蛋白和0.05%叠氮化钠的磷酸盐缓冲盐水（pH 7.4）中冻干。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Paraneoplastic Neuromyelitis Optica Associated with Lung Adenocarcinoma in a Young Woman.
Kyoung Won Baik et al.
Journal of clinical neurology (Seoul, Korea), 14(2), 246-247 (2018-04-10)
Gry Fluge Vindedal et al.
Molecular and cellular neurosciences, 77, 47-52 (2016-11-05)
There is a constitutive production of water in brain. The efflux routes of this excess water remain to be identified. We used basal brain water content as a proxy for the capacity of water exit routes. Basal brain water content
Charles L Howe et al.
Glia, 62(5), 692-708 (2014-02-05)
Neuromyelitis optica (NMO) is a primary astrocyte disease associated with central nervous system inflammation, demyelination, and tissue injury. Brain lesions are frequently observed in regions enriched in expression of the aquaporin-4 (AQP4) water channel, an antigenic target of the NMO
Vanda A Lennon et al.
The Journal of experimental medicine, 202(4), 473-477 (2005-08-10)
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that selectively affects optic nerves and spinal cord. It is considered a severe variant of multiple sclerosis (MS), and frequently is misdiagnosed as MS, but prognosis and optimal treatments differ. A serum
Friederike Tuller et al.
Journal of neuroinflammation, 13(1), 176-176 (2016-07-03)
The discovery of a highly specific antibody against the aquaporin-4 (AQP4) water channel (AQP4-IgG) unified the spectrum of neuromyelitis optica spectrum disorders (NMOSD), which are considered to be antibody-mediated autoimmune diseases. The AQP4 water channel is located on astrocytic end-feet
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