A6134
槟榔碱 氢溴酸盐
≥98% (HPLC), powder
别名:
1,2,5,6-四氢-1-甲基-3-吡啶羧酸甲酯 氢溴酸盐, 1-甲基-1,2,5,6-四氢-3-吡啶羧酸甲酯 氢溴酸盐, 1-甲基-1,2,5,6-四氢烟酸甲酯 氢溴酸盐, 槟榔碇甲酯 氢溴酸盐, 牛油菌素
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关于此项目
经验公式（希尔记法）:
C8H13NO2 · HBr
化学文摘社编号:
分子量:
236.11
UNSPSC Code:
12352100
Beilstein/REAXYS Number:
3914826
MDL number:
InChI key
AXOJRQLKMVSHHZ-UHFFFAOYSA-N
SMILES string
Br[H].COC(=O)C1=CCCN(C)C1
InChI
1S/C8H13NO2.BrH/c1-9-5-3-4-7(6-9)8(10)11-2;/h4H,3,5-6H2,1-2H3;1H
assay
≥98% (HPLC)
form
powder
color
white
mp
172-176 °C (lit.)
solubility
H2O: soluble (Solutions should be freshly prepared.), ethanol: slightly soluble (Solutions should be freshly prepared.)
Gene Information
human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)
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Biochem/physiol Actions
Muscarinic acetylcholine receptor agonist. A constituent of betel nut that may be carcinogenic on prolonged exposure. Cytotoxicity is reduced by antioxidants, such as reduced glutathione or N-acetyl-L-cysteine. Induces ADP ribosylation of histones and chromatid relaxation in spleen and bone marrow cells.
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - Solvent
flash_point_c
87 °C - Solvent
法规信息
新产品
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A C Bartolomeo et al.
Neurobiology of learning and memory, 68(3), 333-342 (1997-12-17)
Male Sprague-Dawley rats, preoperatively trained in a 1-h delay non-match-to-position radial maze task, received bilateral stereotaxic injections of a selective cholinotoxin, ethylcholine aziridinium ion (AF64A: 3 nmol/3 microliters/lateral ventricle). Animals treated with AF64A made significantly more total postdelay errors than
J H Jeng et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 37(7), 751-756 (1999-09-25)
Betel quid (BQ) chewing is associated with an increased risk of oral submucous fibrosis (OSF) and oral cancer in India and many south-east Asian countries. Recently, we have shown that arecoline is cytotoxic to cultured human oral mucosal fibroblasts. This
J R Saikia et al.
Cancer letters, 139(1), 59-65 (1999-07-17)
Arecoline, the major alkaloid of betel nut (Areca catechu L.) and a suspected carcinogen, has been implicated in human cancers of various sites. A considerable portion of the world's population is constantly exposed to arecoline due to the habit of
W H Moos et al.
Journal of pharmaceutical sciences, 81(10), 1015-1019 (1992-10-01)
Arecoline, arecaidine, and a series of derivatives, differing by the presence or absence of methyl groups at positions on the periphery of the molecule, were prepared, and their binding to muscarinic acetylcholine receptors was tested. On the basis of this
A Chatterjee et al.
Cancer letters, 139(1), 23-31 (1999-07-17)
The carcinogenic potentiality of the major alkaloid of betel nut, arecoline (ARC), is well established. This study was undertaken to determine the differences in genotoxic effects of ARC when given by two different routes (oral administration (OA) and intraperitoneal injection
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