A6166
3-乙酰脱氧雪腐镰刀菌烯醇 来源于粉红镰刀菌
from Fusarium roseum
别名:
3α-乙酰呕吐毒素, 3α-乙酰氧基-7α,15-二羟基-12,13-环氧单端孢霉-9-烯-8-酮, 3-AcDON
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关于此项目
经验公式（希尔记法）:
C17H22O7
化学文摘社编号:
分子量:
338.35
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
生物来源
Fusarium roseum
质量水平
表单
powder
储存温度
2-8°C
SMILES字符串
[H][C@]12O[C@]3([H])[C@@H](C[C@@](C)([C@]34CO4)[C@@]1(CO)[C@H](O)C(=O)C(C)=C2)OC(C)=O
InChI
1S/C17H22O7/c1-8-4-11-16(6-18,13(21)12(8)20)15(3)5-10(23-9(2)19)14(24-11)17(15)7-22-17/h4,10-11,13-14,18,21H,5-7H2,1-3H3/t10-,11-,13-,14-,15-,16-,17+/m1/s1
InChI key
ADFIQZBYNGPCGY-HTJQZXIKSA-N
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一般描述
3-乙酰脱氧雪腐镰刀菌烯醇是一种单端孢霉烯族真菌毒素，由镰刀菌 种 分泌。刺激 c-Jun 氨基末端激酶 (JNK)/p38 丝裂原活化蛋白激酶的激活，阻止蛋白质合成。3-乙酰脱氧雪腐镰刀菌烯醇是细胞凋亡的弱诱导剂。
应用
3-乙酰脱氧雪腐镰刀菌烯醇已被用于一项比较两种真菌改善小麦生长、降低镰刀菌根部定殖和抵御真菌毒素的能力的研究。3-乙酰脱氧雪腐镰刀菌烯醇也用于诱导和研究小鼠厌食症。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
高风险级别生物产品--毒素类产品
此项目有
Trichothecene mycotoxins trigger a ribotoxic stress response that activates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase and induces apoptosis
Shifrin VI and Anderson P
The Journal of Biological Chemistry, 274(20), 13985-13992 (1999)
The trichothecene biosynthesis gene cluster of Fusarium graminearum F15 contains a limited number of essential pathway genes and expressed non-essential genes
Kimura M, et al.
Febs Letters, 539(1-3), 105-110 (2003)
Michael Bretz et al.
Molecular nutrition & food research, 50(3), 251-260 (2006-03-08)
Trichothecenes are secondary metabolites produced by several fungi of the Fusarium genus during their growth period. They inhibit protein biosynthesis in eukaryotic cells resulting in numerous toxic effects such as diarrhea, vomiting, and gastro-intestinal inflammation. Considering its occurrence in food
B Huybrechts et al.
Archives of toxicology, 89(11), 1993-2005 (2014-09-12)
A direct, fast and sensitive LC-MS/MS method was developed to measure biomarkers for mycotoxin exposure in human urine. In total, 32 biomarkers were quantitatively or semi-quantitatively measured in 32 urine samples of Belgian volunteers using two injections. All urine samples
A Llorens et al.
International journal of food microbiology, 94(1), 43-54 (2004-06-03)
Various species of Fusarium can produce trichothecene mycotoxins that contaminate food commodities and can represent a risk for human and animal health. In this paper, a full factorial design was applied to study the influence of incubation temperature, water activity
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