A6166
3-乙酰脱氧雪腐镰刀菌烯醇 来源于粉红镰刀菌
from Fusarium roseum
别名:
3α-乙酰呕吐毒素, 3α-乙酰氧基-7α,15-二羟基-12,13-环氧单端孢霉-9-烯-8-酮, 3-AcDON
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关于此项目
经验公式（希尔记法）:
C17H22O7
化学文摘社编号:
分子量:
338.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
powder
Quality level:
产品名称
3-乙酰脱氧雪腐镰刀菌烯醇 来源于粉红镰刀菌, from Fusarium roseum
InChI key
ADFIQZBYNGPCGY-HTJQZXIKSA-N
SMILES string
[H][C@]12O[C@]3([H])[C@@H](C[C@@](C)([C@]34CO4)[C@@]1(CO)[C@H](O)C(=O)C(C)=C2)OC(C)=O
InChI
1S/C17H22O7/c1-8-4-11-16(6-18,13(21)12(8)20)15(3)5-10(23-9(2)19)14(24-11)17(15)7-22-17/h4,10-11,13-14,18,21H,5-7H2,1-3H3/t10-,11-,13-,14-,15-,16-,17+/m1/s1
biological source
Fusarium roseum
form
powder
storage temp.
2-8°C
Quality Level
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Application
3-乙酰脱氧雪腐镰刀菌烯醇已被用于一项比较两种真菌改善小麦生长、降低镰刀菌根部定殖和抵御真菌毒素的能力的研究。3-乙酰脱氧雪腐镰刀菌烯醇也用于诱导和研究小鼠厌食症。
General description
3-乙酰脱氧雪腐镰刀菌烯醇是一种单端孢霉烯族真菌毒素，由镰刀菌 种 分泌。刺激 c-Jun 氨基末端激酶 (JNK)/p38 丝裂原活化蛋白激酶的激活，阻止蛋白质合成。3-乙酰脱氧雪腐镰刀菌烯醇是细胞凋亡的弱诱导剂。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
高风险级别生物产品--毒素类产品
此项目有
Trichothecene mycotoxins trigger a ribotoxic stress response that activates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase and induces apoptosis
Shifrin VI and Anderson P
The Journal of Biological Chemistry, 274(20), 13985-13992 (1999)
The trichothecene biosynthesis gene cluster of Fusarium graminearum F15 contains a limited number of essential pathway genes and expressed non-essential genes
Kimura M, et al.
Febs Letters, 539(1-3), 105-110 (2003)
Michael Bretz et al.
Molecular nutrition & food research, 50(3), 251-260 (2006-03-08)
Trichothecenes are secondary metabolites produced by several fungi of the Fusarium genus during their growth period. They inhibit protein biosynthesis in eukaryotic cells resulting in numerous toxic effects such as diarrhea, vomiting, and gastro-intestinal inflammation. Considering its occurrence in food
Rie Tsuyuki et al.
Journal of agricultural and food chemistry, 59(5), 1760-1766 (2011-02-09)
The effects of cobalt chloride on the production of trichothecene and ergosterol in Fusarium graminearum were examined. Incorporation experiments with (13)C-labeled acetate and leucine confirmed that both 3-acetyldeoxynivalenol and ergosterol were biosynthesized via a mevalonate pathway by the fungus, although
G S Eriksen et al.
Archiv fur Tierernahrung, 57(5), 335-345 (2003-11-19)
The absorption, metabolism and excretion of 3-acetyldeoxynivalenol (3-aDON) in pigs were studied. Pigs with a faecal microflora known to be able to de-epoxidate trichothecenes were used in the experiment. The pigs were fed a commercial diet with 3-aDON added in
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