A6185
钙蛋白酶抑制剂I
synthetic (organic), ≥97% (TLC), cysteine protease inhibitor, powder
别名:
ALLN, Ac-LLnL-CHO, MG-101, N-乙酰基-L-亮氨酰基-L-亮氨酰基-L-正亮氨酸醛, N-乙酰基-亮氨酸-亮氨酸-正亮氨酸醛
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选择尺寸
关于此项目
经验公式（希尔记法）:
C20H37N3O4
化学文摘社编号:
分子量:
383.53
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
7656053
产品名称
钙蛋白酶抑制剂I, ≥97% (TLC), powder
color
white
form
powder
InChI
1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1
SMILES string
[H]C(=O)[C@H](CCCC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O
InChI key
FMYKJLXRRQTBOR-BZSNNMDCSA-N
biological source
synthetic (organic)
assay
≥97% (TLC)
solubility
DMSO: soluble, ethanol: soluble
storage temp.
−20°C
Quality Level
Gene Information
human ... CAPN1(823), CTSB(1508), PSMA1(5682)
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Application
钙蛋白酶抑制剂I已被用于：
- 作为蛋白酶抑制剂混合物的成分，用于凝胶位移分析
- 处理HeLa细胞培养物
- 在26 S蛋白酶体抑制测定中抑制26 S蛋白酶体
Biochem/physiol Actions
可引发HL-60细胞的细胞凋亡，但可阻断地塞米松诱导的胸腺细胞凋亡和环己酰亚胺诱导的间质细胞凋亡。 抑制细胞周期蛋白B降解，将细胞周期停滞在G1/S和中/后期。 阻断LPS在巨噬细胞中诱导一氧化氮合酶。
钙蛋白酶抑制剂I可抑制肿瘤坏死因子诱导的（TNF诱导的）聚（ADP-核糖）聚合酶（PARP）和钙蛋白酶抑制素的裂解。它还可抑制氧/葡萄糖剥夺（OGD）诱导的caspase-12和Bcl-xL的裂解。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
J M Griscavage et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(8), 3308-3312 (1996-04-16)
The objective of this study was to elucidate the role of the proteasome pathway or multicatalytic proteinase complex in the induction of immunologic nitric oxide (NO) synthase (iNOS) in rat alveolar macrophages activated by lipopolysaccharide. Macrophages were incubated in the
Cleavage of the calpain inhibitor, calpastatin, during apoptosis
Porn-Ares M I, et al.
Cell Death and Differentiation, 5(12), 1028-1028 (1998)
S W Sherwood et al.
Proceedings of the National Academy of Sciences of the United States of America, 90(8), 3353-3357 (1993-04-15)
The cytotoxic neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal (ALLN) inhibits cell-cycle progression in CHO cells, affecting the G1/S and metaphase-anaphase transition points, as well as S phase. Mitotic arrest induced by ALLN is associated with the inhibition of cyclin B degradation.
Q Lu et al.
Archives of biochemistry and biophysics, 334(1), 175-181 (1996-10-01)
Recent investigations indicate that proteolysis is an important event in generation of the apoptosis phenotype. Although various proteases have been suggested to be candidates for this proteolysis, the results from different laboratories are inconsistent. In the present studies, HL-60 cells
The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles
Mayor T, et al.
Journal of Cell Science, 115(16), 3275-3284 (2002)
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