A6553
DL -2-氨基-5-磷戊酸 锂盐
~95%
别名:
DL-2-Amino-5-phosphonopentanoic acid, AP-5
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关于此项目
线性分子式:
C5H11NO5PLi
化学文摘社编号:
分子量:
203.06
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
产品名称
DL -2-氨基-5-磷戊酸 锂盐, ~95%
InChI
1S/C5H12NO5P.Li.H/c6-4(5(7)8)2-1-3-12(9,10)11;;/h4H,1-3,6H2,(H,7,8)(H2,9,10,11);;
SMILES string
[Li].NC(CCCP(O)(O)=O)C(O)=O
InChI key
QIVHTKSFMZBERS-UHFFFAOYSA-N
assay
~95%
form
powder
technique(s)
ligand binding assay: suitable
color
white to off-white
Quality Level
Gene Information
rat ... Grik1(29559), Grin2a(24409), Grin2b(24410)
Biochem/physiol Actions
Anticonvulsant; potent and selective antagonist for NMDA receptors.
DL-2-Amino-5-phosphonovaleric acid is a selective N-methyl-d-aspartate (NMDA) receptor antagonist used frequently in studies of neurological processes
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Guan Cao et al.
Journal of neurophysiology, 107(3), 902-912 (2011-11-25)
Long-term potentiation (LTP) is a form of synaptic plasticity thought to underlie memory; thus knowing its developmental profile is fundamental to understanding function. Like memory, LTP has multiple phases with distinct timing and mechanisms. The late phase of LTP (L-LTP)
A Osorio-Espinoza et al.
Neuroscience, 176, 20-31 (2011-01-05)
The globus pallidus, a neuronal nucleus involved in the control of motor behavior, expresses high levels of histamine H(3) receptors (H(3)Rs) most likely located on the synaptic afferents to the nucleus. In this work we studied the effect of the
Jessica M André et al.
Neuropharmacology, 60(4), 617-625 (2010-12-21)
NMDA glutamate receptors (NMDARs) and nicotinic acetylcholine receptors (nAChRs) are both involved in learning and synaptic plasticity. Increasing evidence suggests processes mediated by these receptors may interact to modulate learning; however, little is known about the neural substrates involved in
Thomas K Fung et al.
Synapse (New York, N.Y.), 65(7), 677-686 (2010-12-31)
Synaptic plasticity may depend not only on the afferent fibers but also on the recipient structure. The medial perforant path (MPP) from the entorhinalcortex projects to both the dentate gyrus (DG) and CA3, resulting in excitatory postsynaptic potentials (EPSPs) in
Brandon S Martin et al.
Journal of neurophysiology, 112(4), 890-902 (2014-05-23)
Fragile X syndrome (FXS) is the leading cause of inherited intellectual disability. Comorbidities of FXS such as autism are increasingly linked to imbalances in excitation and inhibition (E/I) as well as dysfunction in GABAergic transmission in a number of brain
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