A6566
2-羟色胺
≥98% (TLC), solid
别名:
3-Amino-2-(4-chlorophenyl)-2-hydroxypropanesulfonic acid
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关于此项目
经验公式（希尔记法）:
C9H12ClNO4S
化学文摘社编号:
分子量:
265.71
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.32
质量水平
方案
≥98% (TLC)
表单
solid
颜色
white
溶解性
H2O: 1 mg/mL
0.1 M HCl: 1.2 mg/mL
methanol: 1.4 mg/mL
DMSO: 28 mg/mL
0.1 M NaOH: 9.5 mg/mL
SMILES字符串
NCC(O)(CS(O)(=O)=O)c1ccc(Cl)cc1
InChI
1S/C9H12ClNO4S/c10-8-3-1-7(2-4-8)9(12,5-11)6-16(13,14)15/h1-4,12H,5-6,11H2,(H,13,14,15)
InChI key
WBSMZVIMANOCNX-UHFFFAOYSA-N
基因信息
human ... GABBR1(2550), GABBR2(9568)
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相关类别
生化/生理作用
Potent and selective antagonist at GABAB receptors.
警示用语：
Danger
危险声明
危险分类
Skin Corr. 1B
储存分类代码
8A - Combustible corrosive hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
D R Curtis et al.
Neuroscience letters, 92(1), 97-101 (1988-09-23)
When administered microelectrophoretically, a sulphonic acid derivative of baclofen, 3-amino-2-(4-chlorophenyl)-2-hydroxy-propylsulphonic acid, reversibly reduced the presynaptic reduction by (-)-baclofen of the monosynaptic excitation of spinal interneurones by impulses in low threshold primary afferent fibres of the cat as well as the
K Obrietan et al.
Journal of neurophysiology, 82(1), 94-102 (1999-07-13)
In the mature nervous system excitatory neurotransmission mediated by glutamate is balanced by the inhibitory actions of GABA. However, during early development, GABA acting at the ligand-gated GABAA Cl- channel also exerts excitatory actions. This raises a question as to
Jacques H Abraini et al.
Anesthesia and analgesia, 96(3), 746-749 (2003-02-25)
Inhaled anesthetics, including the gaseous anesthetics nitrous oxide and xenon, are thought to act by interacting directly with ion-channel receptors. In contrast, little is known about the mechanism of action of inert gases that show only narcotic potency at high
Nonna A Otmakhova et al.
Journal of neurophysiology, 92(4), 2027-2039 (2004-05-28)
CA1 pyramidal cells receive two major excitatory inputs: the perforant path (PP) terminates in the most distal dendrites, whereas the Schaffer collaterals (SC) terminate more proximally. We have examined the mechanism of the afterhyperpolarization (AHP) that follows single subthreshold excitatory
María M Bonaventura et al.
European journal of pharmacology, 677(1-3), 188-196 (2012-01-03)
γ-Aminobutyric acid (GABA) inhibits insulin secretion through GABA(B) receptors in pancreatic β-cells. We investigated whether GABA(B) receptors participated in the regulation of glucose homeostasis in vivo. BALB/c mice acutely pre-injected with the GABA(B) receptor agonist baclofen (7.5mg/kg, i.p.) presented glucose
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